| Title: | Serum liver function profiles in coking workers |
| Author(s): | Wu MT; Mao IF; Wypij D; Ho CK; Chen JR; Christiani DC; |
| Address: | "Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA" |
| DOI: | 10.1002/(sici)1097-0274(199711)32:5<478::aid-ajim7>3.0.co;2-o |
| ISSN/ISBN: | 0271-3586 (Print) 0271-3586 (Linking) |
| Abstract: | "Coking workers are regularly exposed to coke oven emissions (COE), which consist mainly of polycyclic aromatic hydrocarbons and volatile organic compounds. In a previous cross-sectional study, we found that coking and by-product workers with heavy exposure to COE in the older of two coke operation areas in Taiwan had higher serum activities of hepatic aminotransferase than the controls. In this study, we further examine the relationship of exposure to COE with liver function profiles in coking workers. Liver function profiles included serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and total bilirubin (BIL). The exposed group included 88 workers working 3 months or more in the older coke oven plant. Fifty-nine referents, not visiting the coke operation areas in the last 3 months, came from the administrative area in the same company. Each participant wore a personal monitor that was used to measure benzene soluble fraction (BSF) of total particulates, as a surrogate of COE, for 3 consecutive days between August 1995 and February 1996. Serum liver function profiles, hepatitis B surface antigens, and anti-hepatitis C antibodies were examined in the morning following the exposure measurements. Exposure levels were categorized by exposure situations (high, medium, low) among coking workers. The high exposure group (n = 23) worked topside of the oven. The medium exposure group (n = 44) worked at the sideoven for more than 4 hr/day, whereas the low exposure group (n = 21) worked at the sideoven for less than 4 hr/day and mostly remained in the control rooms. The low exposure group was used as an internal comparison group. The median BSF concentrations for various exposure situations were as follows, high exposure group: 372 micrograms/m3, medium exposure group: 61 micrograms/m3, low exposure group: 49 micrograms/m3, and referents: 10 micrograms/m3. The coking workers (n = 88) did not significantly differ from the referents (n = 59) in any of the liver function profiles. Excluding the referents, workers in the high exposure group had a mean AST level that was 31% higher (95% confidence interval (CI) = 9-57%) and a mean ALT level that was 46% higher (95% CI = 7-98%) than those in the low exposure group after adjusting for appropriate confounders in multivariate models. The prevalence of an abnormal hepatocellular pattern (AST > 37 IU/L or ALT > 39 IU/L) was more common in the high exposure group than in the low exposure group (adjusted odds ratio = 4.4; 95% CI = 0.9-22.6). However, these associations were not found in GGT, ALP, or BIL. After controlling for the possible effects of nonoccupational factors on serum activity of AST and ALT, we conclude that increased AST and ALT levels among topside coking workers may be caused by heavy inhalation exposure to COE. Additionally, the adverse hepatic effect seems to be caused by a mixture of hazards, rather than a unique identifiable chemical" |
| Keywords: | "Adult Air Pollutants, Occupational/*adverse effects Benzene/*adverse effects/analysis Case-Control Studies Chemical and Drug Induced Liver Injury Coke/*adverse effects Humans Linear Models Liver/*drug effects Liver Diseases/*epidemiology Liver Function Te;" |
| Notes: | "MedlineWu, M T Mao, I F Wypij, D Ho, C K Chen, J R Christiani, D C eng ES00002/ES/NIEHS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1997/11/05 Am J Ind Med. 1997 Nov; 32(5):478-86. doi: 10.1002/(sici)1097-0274(199711)32:5<478::aid-ajim7>3.0.co; 2-o" |
