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Toxicol Appl Pharmacol

Title:		"Parental exposure to 2,2',4,4'5 - pentain polybrominated diphenyl ethers (BDE-99) causes thyroid disruption and developmental toxicity in zebrafish"
Author(s):		Wu L; Li Y; Ru H; Xie H; Yao F; Ni Z; Zhong L;
Address:		"National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 200120, China; Observation Station for Fishery Resource and Environment in Upper-Middle Reaches of Yangtze River (Ministry of Agriculture), Key Laboratory of Freshwater Biodiversity Conservation (Ministry of Agriculture), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China. Observation Station for Fishery Resource and Environment in Upper-Middle Reaches of Yangtze River (Ministry of Agriculture), Key Laboratory of Freshwater Biodiversity Conservation (Ministry of Agriculture), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China. Observation Station for Fishery Resource and Environment in Upper-Middle Reaches of Yangtze River (Ministry of Agriculture), Key Laboratory of Freshwater Biodiversity Conservation (Ministry of Agriculture), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China; College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China. Observation Station for Fishery Resource and Environment in Upper-Middle Reaches of Yangtze River (Ministry of Agriculture), Key Laboratory of Freshwater Biodiversity Conservation (Ministry of Agriculture), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China. Electronic address: nizhaoh@yfi.ac.cn. Observation Station for Fishery Resource and Environment in Upper-Middle Reaches of Yangtze River (Ministry of Agriculture), Key Laboratory of Freshwater Biodiversity Conservation (Ministry of Agriculture), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China. Electronic address: zhonglq@yfi.ac.cn"
Journal Title:		Toxicol Appl Pharmacol
Year:		2019
Volume:		20190410
Issue:
Page Number:		11 - 18
DOI:		10.1016/j.taap.2019.04.008
ISSN/ISBN:		1096-0333 (Electronic) 0041-008X (Linking)
Abstract:		"Although polybrominated diphenyl ethers (PBDEs) are known to disturb thyroid hormone signaling, the mechanisms underlying the effects of 2,2',4,4'5 - pentain polybrominated diphenyl ethers (BDE-99) in fish remain unclear. In order to reveal these mechanisms, adult zebrafish (Danio rerio) were exposed to different concentrations of BDE-99 (0, 0.5, 5, or 50?ª+mug/L) for 28?ª+days and spawned by mating naturally in clean water (without BDE-99). Females exposed to BDE-99 showed significantly lowered thyroxine (T4) levels. Expression of transthyretin (ttr) and uridine diphosphate glucuronosyl transferase (ugt1ab) were down-regulated and up-regulated, respectively. Triiodothyronine (T3) levels in the 0.5?ª+mug/L BDE-99 exposure group was significantly increased. Males showed significantly increased T3 levels, and lowered T4 levels, which were associated with up-regulated and down-regulated expression of deiodinase 2 (deio2) and ugt1ab, respectively. Exposure of adult zebrafish to BDE-99 lead to significantly increased T4 in the 0.5?ª+mug/L BDE-99 exposure group, but in the 50?ª+mug/L BDE-99 exposure group there was significantly reduced T4 in F1 larvae and altered mRNA transcription in the hypothalamic-pituitary-thyroid-liver (HPTL) axis. The offspring also showed reduced survival rates, and body length and elevated malformation rates. This study is the first in zebrafish to show that parental zebrafish exposure to BDE-99 can lead to developmental toxicity and thyroid disruption in the offspring"
Keywords:		"Animals Dose-Response Relationship, Drug Embryo, Nonmammalian/abnormalities/*drug effects/metabolism Female Gene Expression Regulation, Developmental Glucuronosyltransferase/genetics/metabolism Halogenated Diphenyl Ethers/*toxicity Hypothalamo-Hypophyseal;"
Notes:		"MedlineWu, Luyin Li, Yunfeng Ru, Huijun Xie, Huaxiao Yao, Fan Ni, Zhaohui Zhong, Liqiao eng Comparative Study Research Support, Non-U.S. Gov't 2019/04/13 Toxicol Appl Pharmacol. 2019 Jun 1; 372:11-18. doi: 10.1016/j.taap.2019.04.008. Epub 2019 Apr 10"