« Previous AbstractSumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast    Next AbstractSpecificity of extrafloral nectar induction by herbivores differs among native and invasive populations of tallow tree »

J Exp Biol

Title:		Regulation of behaviorally associated gene networks in worker honey bee ovaries
Author(s):		Wang Y; Kocher SD; Linksvayer TA; Grozinger CM; Page RE; Amdam GV;
Address:		"School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA. ying.wang.6@asu.edu"
Journal Title:		J Exp Biol
Year:		2012
Volume:		215
Issue:		Pt 1
Page Number:		124 - 134
DOI:		10.1242/jeb.060889
ISSN/ISBN:		1477-9145 (Electronic) 0022-0949 (Print) 0022-0949 (Linking)
Abstract:		"Several lines of evidence support genetic links between ovary size and division of labor in worker honey bees. However, it is largely unknown how ovaries influence behavior. To address this question, we first performed transcriptional profiling on worker ovaries from two genotypes that differ in social behavior and ovary size. Then, we contrasted the differentially expressed ovarian genes with six sets of available brain transcriptomes. Finally, we probed behavior-related candidate gene networks in wild-type ovaries of different sizes. We found differential expression in 2151 ovarian transcripts in these artificially selected honey bee strains, corresponding to approximately 20.3% of the predicted gene set of honey bees. Differences in gene expression overlapped significantly with changes in the brain transcriptomes. Differentially expressed genes were associated with neural signal transmission (tyramine receptor, TYR) and ecdysteroid signaling; two independently tested nuclear hormone receptors (HR46 and ftz-f1) were also significantly correlated with ovary size in wild-type bees. We suggest that the correspondence between ovary and brain transcriptomes identified here indicates systemic regulatory networks among hormones (juvenile hormone and ecdysteroids), pheromones (queen mandibular pheromone), reproductive organs and nervous tissues in worker honey bees. Furthermore, robust correlations between ovary size and neuraland endocrine response genes are consistent with the hypothesized roles of the ovaries in honey bee behavioral regulation"
Keywords:		"Animals Bees/*genetics Female Gene Regulatory Networks *Genes, Insect Ovary/metabolism Social Behavior;"
Notes:		"MedlineWang, Ying Kocher, Sarah D Linksvayer, Timothy A Grozinger, Christina M Page, Robert E Jr Amdam, Gro V eng P01 AG022500/AG/NIA NIH HHS/ P01 AG22500/AG/NIA NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England 2011/12/14 J Exp Biol. 2012 Jan 1; 215(Pt 1):124-34. doi: 10.1242/jeb.060889"