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Chem Res Toxicol

Title:		Volatile Organic Compounds in Mainstream Smoke of Sixty Domestic Little Cigar Products
Author(s):		Vu AT; Hassink MD; Taylor KM; McGuigan M; Blasiole A; Valentin-Blasini L; Williams K; Watson CH;
Address:		"Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Calverton, Maryland 20705, United States. Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States. Battelle Memorial Institute, Atlanta, Georgia 30329, United States"
Journal Title:		Chem Res Toxicol
Year:		2021
Volume:		20210129
Issue:		3
Page Number:		704 - 712
DOI:		10.1021/acs.chemrestox.0c00215
ISSN/ISBN:		1520-5010 (Electronic) 0893-228X (Print) 0893-228X (Linking)
Abstract:		"The mainstream smoke yields of five volatile organic compounds (VOCs) were determined from 60 commercial U.S. little cigar products under ISO 3308 and Canadian Intense (CI) smoking regimens on linear smoking machines using a gas sampling bag collection. The five VOCs, 1,3-butadiene, acrylonitrile, benzene, isoprene, and toluene were analyzed using an automated GC/MS analytical method validated for measuring various VOCs in mainstream smoke. The VOCs range in amounts from micrograms to milligrams per little cigar. VOC deliveries vary considerably among the little cigar products under the ISO smoking regimen primarily due to varying filter ventilation. Under the CI smoking regimen where filter ventilation is blocked, the delivery range narrows, although individual and total VOC yields are approximately 2 fold higher than those under the ISO smoking regimen. Correlation analysis reveals strong associations between acrylonitrile and 1,3-butadiene or toluene under the ISO smoking regimen. Compared to cigarettes, little cigars delivered substantially higher VOC mainstream smoke yields under both ISO and CI smoking regimens. Moreover, little cigar smoke also contains higher VOCs than cigarette smoke when adjusted for mass of tobacco"
Keywords:		Smoke/*analysis Tobacco Products/*analysis Volatile Organic Compounds/*analysis;
Notes:		"MedlineVu, An T Hassink, Matthew D Taylor, Kenneth M McGuigan, Megan Blasiole, Ashley Valentin-Blasini, Liza Williams, Katrice Watson, Clifford H eng CC999999/ImCDC/Intramural CDC HHS/ FD/FDA HHS/ Research Support, U.S. Gov't, P.H.S. 2021/01/30 Chem Res Toxicol. 2021 Mar 15; 34(3):704-712. doi: 10.1021/acs.chemrestox.0c00215. Epub 2021 Jan 29"