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J Pediatr Hematol Oncol

Title:		Prediction of Bloodstream Infection in Pediatric Acute Leukemia by Microbiota and Volatile Organic Compounds Analysis
Author(s):		van de Velde ME; El Hassani SEM; Kaspers GJL; Broertjes J; Benninga MA; de Boer NKH; Budding AE; de Meij TGJ;
Address:		"Departments of Pediatric Oncology. Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam. Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam. Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands. Department of Gastroenterology and Hepatology, Amsterdam UMC, Vrije Universiteit Amsterdam, AG&M Research Institute. inBiome BV, Amsterdam"
Journal Title:		J Pediatr Hematol Oncol
Year:		2022
Volume:		44
Issue:		1
Page Number:		e152 - e159
DOI:		10.1097/MPH.0000000000002210
ISSN/ISBN:		1536-3678 (Electronic) 1077-4114 (Linking)
Abstract:		"INTRODUCTION: Bloodstream infections (BSIs) cause treatment-related mortality in pediatric acute leukemia. We explored the potential of intestinal microbiota and fecal volatile organic compounds (VOCs) analyses to predict BSI. METHODS: In this case-control study, fecal samples of pediatric acute leukemia patients were collected. Microbiota composition and fecal VOC profiles of BSI cases and matched non-BSI controls were compared. RESULTS: In total, 6 patients were included, of which 1 developed BSI and 1 neutropenic fever. Both showed reduced microbial diversity and stability of Bacteroidetes. In the BSI case, Pantoea was identified 15 days before BSI. Significant differences in fecal VOC profiles were measured between the case and controls. CONCLUSION: Microbiota and fecal VOC could serve as biomarkers to predict BSI in pediatric leukemia"
Keywords:		"Adolescent Child Child, Preschool *Feces/chemistry/microbiology Female *Gastrointestinal Microbiome Humans *Leukemia, Myeloid, Acute/blood/microbiology Male Pilot Projects *Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood/microbiology Sepsis/*blood Vo;"
Notes:		"Medlinevan de Velde, Mirjam E El Hassani, Sofia El Manouni Kaspers, Gert Jan L Broertjes, Jorrit Benninga, Marc A de Boer, Nanne K H Budding, Andries E de Meij, Tim G J eng Clinical Trial 2021/06/17 J Pediatr Hematol Oncol. 2022 Jan 1; 44(1):e152-e159. doi: 10.1097/MPH.0000000000002210"