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Arch Med Res

Title:		Volatolome of the Female Genitourinary Area: Toward the Metabolome of Cervical Cancer
Author(s):		Rodriguez-Esquivel M; Rosales J; Castro R; Apresa-Garcia T; Garay O; Romero-Morelos P; Marrero-Rodriguez D; Taniguchi-Ponciano K; Lopez-Romero R; Guerrero-Flores H; Morales B; Mendoza-Rodriguez M; Mosso-Lara D; Nunez-Nolasco I; Castro-Alba P; Meza-Toledo SE; Salcedo M;
Address:		"Laboratorio de Oncologia Genomica, Unidad de Investigacion Medica en Enfermedades Oncologicas, UMAE Hospital de Oncologia, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. Facultad de Quimica, Universidad La Salle, Ciudad de Mexico, Mexico. Soluciones en Instrumentacion, SA de CV, Monterrey, N.L, Mexico. Servicio de Braquiterapia, UMAE Hospital de Oncologia, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. Universidad Politecnica de Huatusco, Veracruz, Mexico. Direccion de Prestaciones Medicas, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. Departamento de Bioquimica, Laboratorio de Quimioterapia Experimental, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Campus Lazaro Cardenas, Ciudad de Mexico, Mexico. Laboratorio de Oncologia Genomica, Unidad de Investigacion Medica en Enfermedades Oncologicas, UMAE Hospital de Oncologia, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. Electronic address: masava89@gmail.com"
Journal Title:		Arch Med Res
Year:		2018
Volume:		20180419
Issue:		1
Page Number:		27 - 35
DOI:		10.1016/j.arcmed.2018.04.004
ISSN/ISBN:		1873-5487 (Electronic) 0188-4409 (Linking)
Abstract:		"BACKGROUND AND AIMS: Different Volatile Organic Compounds (VOCs) obtained from several human fluids (volatolome) has been reported as potential biomarkers for a great variety of diseases including cancer. At present, volatolomic profile data of the female genital area is scarce. METHODS: To identify the VOCs related to the female genitourinary area of healthy and Cervical Cancer (CC)-affected women used a pad, as a non-invasive tool for sample gathering was necessary. Used pads were analyzed by Gas Chromatography-Mass Spectrometry. The data were subjected to Principal Component Analysis looking for a possible spectrum of VOCs that could help identify CC-affected patients. The diagnostic role of the VOCs was validated through Receiver Operating Characteristic (ROC) analysis. The area below the curve and the diagnostic sensitivity and specificity values were also evaluated. RESULTS: The data showed great differences between female cancer and healthy patients groups; most of these VOCs belonging to the alkanes chemical classes. A group of VOCs were identified as common among CC patients, while others VOCs for healthy females. The ROC curve showed an optimal reach to diagnosis (89%), returning a 93% rate for sensitivity and specificity, indicating the VOCs identified in the samples could differentiate cancer patients from healthy females. CONCLUSIONS: In summary, we have detected and identified specific VOCs from healthy women that are not present in CC-affected females and VOCs specific of CC-affected women. We are strengthening our findings to aid in the detection of VOCs that are potential biomarkers for cervical tumors"
Keywords:		"Adult Biomarkers, Tumor/*analysis Breath Tests Feces Female Gas Chromatography-Mass Spectrometry Humans Metabolome/*physiology Principal Component Analysis ROC Curve Sensitivity and Specificity Uterine Cervical Neoplasms/*metabolism Volatile Organic Compo;"
Notes:		"MedlineRodriguez-Esquivel, Miriam Rosales, Juan Castro, Rafael Apresa-Garcia, Teresa Garay, Onix Romero-Morelos, Pablo Marrero-Rodriguez, Daniel Taniguchi-Ponciano, Keiko Lopez-Romero, Ricardo Guerrero-Flores, Hector Morales, Betsabe Mendoza-Rodriguez, Monica Mosso-Lara, Dejanira Nunez-Nolasco, Itzalia Castro-Alba, Paola Meza-Toledo, Sergio E Salcedo, Mauricio eng Research Support, Non-U.S. Gov't 2018/04/24 Arch Med Res. 2018 Jan; 49(1):27-35. doi: 10.1016/j.arcmed.2018.04.004. Epub 2018 Apr 19"