| Title: | Volatile organic compounds in bile can distinguish pancreatic cancer from chronic pancreatitis: a prospective observational study |
| Author(s): | Navaneethan U; Spencer C; Zhu X; Vargo JJ; Grove D; Dweik RA; |
| Address: | "Center for Interventional Endoscopy, Orlando, Florida, United States. Department of Gastroenterology and Hepatology, University of South Alabama College of Medicine, Mobile, Alabama, United States. Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States. Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland, Ohio, United States. Pathobiology, Lerners Research Institute, Cleveland Clinic, Cleveland, Ohio, United States" |
| ISSN/ISBN: | 1438-8812 (Electronic) 0013-726X (Linking) |
| Abstract: | "BACKGROUND: Early and accurate diagnosis of pancreatic cancer is important. Our aim was to identify potential volatile organic compounds (VOCs) in the bile that can help distinguish pancreatic cancer from chronic pancreatitis. METHODS: In this prospective observational study, bile was aspirated from patients undergoing endoscopic retrograde cholangiopancreatography for chronic pancreatitis and pancreatic cancer, and the gaseous headspace was analyzed using mass spectrometry. RESULTS: The study included a discovery cohort of 57 patients (46 pancreatic cancer, 11 chronic pancreatitis) and a validation cohort of 31 patients (19 and 12, respectively). Using logistic regression analysis, the model [0.158 x age + 9.747 x log (ammonia) - 3.994 x log (acetonitrile) + 5.044 x log (trimethylamine) - 30.23] successfully identified patients with pancreatic cancer with a sensitivity of 93.5 % and specificity of 100 % (likelihood ratio 40.9, area under the curve 0.98, 95 % confidence interval 0.95 - 1.00). The diagnostic accuracy of this model was confirmed in the second independent validation cohort. CONCLUSION: The measurement of VOCs in bile helped to accurately distinguish pancreatic cancer from chronic pancreatitis" |
| Keywords: | "Bile Child Cholangiopancreatography, Endoscopic Retrograde Humans *Pancreatic Neoplasms/diagnosis *Pancreatitis, Chronic/diagnosis Prospective Studies *Volatile Organic Compounds;" |
| Notes: | "MedlineNavaneethan, Udayakumar Spencer, Chad Zhu, Xiang Vargo, John J Grove, David Dweik, Raed A eng Clinical Trial Observational Study Research Support, Non-U.S. Gov't Germany 2020/09/08 Endoscopy. 2021 Jul; 53(7):732-736. doi: 10.1055/a-1255-9169. Epub 2020 Sep 4" |
