| Title: | Simulated downwind coal combustion emissions for laboratory inhalation exposure atmospheres |
| Author(s): | McDonald JD; White RK; Holmes T; Mauderly J; Zielinska B; Chow JC; |
| Address: | "Lovelace Respiratory Research Institute , Albuquerque, NM 87108, USA. jmcdonal@lrri.org" |
| DOI: | 10.3109/08958378.2012.661800 |
| ISSN/ISBN: | 1091-7691 (Electronic) 0895-8378 (Linking) |
| Abstract: | "Exposure atmospheres for rodent inhalation toxicology studies were generated to enable the evaluation of biological responses to a simulated downwind coal combustion atmosphere. A composition representing a single test case of emissions components as they may exist tens to hundreds of miles from a coal-fired power plant was developed. The particulate matter (PM) was 99% sulfate (partially neutralized) and 1% ash. Sulfate was present in equimolar concentrations to sulfur dioxide (SO(2)). Gaseous nitrogen species included nitrogen monoxide (NO), nitrogen dioxide (NO(2)), and nitric acid (HNO(3)). At the high-exposure level, the gaseous species target concentrations were 0.2 ppm SO(2), 0.6 ppm NO, 0.3 ppm NO(2), and 0.1 ppm HNO(3). The test atmosphere was produced by combining effluent from a laboratory coal combustor with sulfate generated through an evaporation-condensation generator. These atmospheres were used to conduct inhalation toxicology studies that have been previously reported" |
| Keywords: | "Administration, Inhalation *Air Pollutants/analysis Ammonia/analysis *Coal Metals/analysis Nitrogen Oxides/analysis *Particulate Matter/analysis *Power Plants Sulfates/analysis Sulfur Dioxide/analysis Toxicity Tests/*methods Volatile Organic Compounds/ana;" |
| Notes: | "MedlineMcDonald, Jacob D White, Richard K Holmes, Tom Mauderly, Joe Zielinska, Barbara Chow, Judith C eng Research Support, U.S. Gov't, Non-P.H.S. England 2012/04/11 Inhal Toxicol. 2012 Apr; 24(5):310-9. doi: 10.3109/08958378.2012.661800" |
