| Title: | Plant metabolism of nematode pheromones mediates plant-nematode interactions |
| Author(s): | Manohar M; Tenjo-Castano F; Chen S; Zhang YK; Kumari A; Williamson VM; Wang X; Klessig DF; Schroeder FC; |
| Address: | "Boyce Thompson Institute, Ithaca, NY, 14853, USA. Plant Pathology and Plant-Microbe Biology Section, School of Integrative Plant Science, Cornell University, Ithaca, NY, 14853, USA. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA. Department of Plant Pathology, University of California, Davis, CA, 95616, USA. Robert W. Holley Center for Agriculture and Health, USDA-ARS, Ithaca, NY, 14853, USA. Boyce Thompson Institute, Ithaca, NY, 14853, USA. dfk8@cornell.edu. Plant Pathology and Plant-Microbe Biology Section, School of Integrative Plant Science, Cornell University, Ithaca, NY, 14853, USA. dfk8@cornell.edu. Boyce Thompson Institute, Ithaca, NY, 14853, USA. schroeder@cornell.edu. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA. schroeder@cornell.edu" |
| DOI: | 10.1038/s41467-019-14104-2 |
| ISSN/ISBN: | 2041-1723 (Electronic) 2041-1723 (Linking) |
| Abstract: | "Microorganisms and nematodes in the rhizosphere profoundly impact plant health, and small-molecule signaling is presumed to play a central role in plant rhizosphere interactions. However, the nature of the signals and underlying mechanisms are poorly understood. Here we show that the ascaroside ascr#18, a pheromone secreted by plant-parasitic nematodes, is metabolized by plants to generate chemical signals that repel nematodes and reduce infection. Comparative metabolomics of plant tissues and excretions revealed that ascr#18 is converted into shorter side-chained ascarosides that confer repellency. An Arabidopsis mutant defective in two peroxisomal acyl-CoA oxidases does not metabolize ascr#18 and does not repel nematodes, indicating that plants, like nematodes, employ conserved peroxisomal beta-oxidation to edit ascarosides and change their message. Our results suggest that plant-editing of nematode pheromones serves as a defense mechanism that acts in parallel to conventional pattern-triggered immunity, demonstrating that plants may actively manipulate chemical signaling of soil organisms" |
| Keywords: | Acyl-CoA Oxidase Animals Arabidopsis/immunology/*metabolism/*parasitology Host-Parasite Interactions/*physiology Solanum lycopersicum Metabolomics Nematoda/*metabolism Oxidation-Reduction Pheromones/*metabolism Plant Diseases/immunology/parasitology Plant; |
| Notes: | "MedlineManohar, Murli Tenjo-Castano, Francisco Chen, Shiyan Zhang, Ying K Kumari, Anshu Williamson, Valerie M Wang, Xiaohong Klessig, Daniel F Schroeder, Frank C eng R35 GM131877/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. England 2020/01/12 Nat Commun. 2020 Jan 10; 11(1):208. doi: 10.1038/s41467-019-14104-2" |
