| Title: | Quantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice |
| Author(s): | Liu YJ; Guo HF; Zhang JX; Zhang YH; |
| Address: | "State Key Laboratory of Integrated Management of Pest Insects and Rodents in Agriculture, Institute of Zoology, Chinese Academy of Sciences, Beichen West Road 1-5, Chaoyang District, Beijing, 100101, China. School of Life Science and Technology, Nanyang Normal University, 1638 Wolong Road Nanyang, Henan, 473061, China. State Key Laboratory of Integrated Management of Pest Insects and Rodents in Agriculture, Institute of Zoology, Chinese Academy of Sciences, Beichen West Road 1-5, Chaoyang District, Beijing, 100101, China. zhangjx@ioz.ac.cn. State Key Laboratory of Integrated Management of Pest Insects and Rodents in Agriculture, Institute of Zoology, Chinese Academy of Sciences, Beichen West Road 1-5, Chaoyang District, Beijing, 100101, China. zhangyh@ioz.ac.cn" |
| DOI: | 10.1038/s41598-017-02259-1 |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "In this study, we examined how urine-borne volatile compounds (UVCs) and darcin of male mice are inherited from parents and interact to modulate the olfactory preferences of females using two inbred strains of mice, C57Bl/6 (C57) and BALB/c (BALB), and their reciprocal hybrids (BC = BALBfemale symbolx C57male symbol; CB = C57female symbol x BALBmale symbol). Chemical analysis revealed that the UVCs of C57BL/6 males were quantitatively distinguishable from those of BALB/c males. Darcin was detected in C57 urine, but not in BALB urine. The levels of UVCs and darcin in both BC and CB were intermediate between those of C57 and BALB. Behaviourally, C57 females consistently preferred BALB male urine over C57 or CB males despite that there are trace amounts of darcin in BALB urine. However, the preference for BALB urine disappeared in contact two-choice tests of BALB vs. BC pairs, and restored when recombinant darcin was added to BALB male urine. Our results suggested that both UVCs and darcin in male mice are quantitatively inherited and interact to affect the olfactory preferences of females" |
| Keywords: | "Animals Female Intercellular Signaling Peptides and Proteins Male *Mating Preference, Animal Mice Mice, Inbred BALB C Mice, Inbred C57BL *Olfactory Perception Proteins/*genetics/metabolism Quantitative Trait, Heritable Sex Attractants/*genetics/metabolism;" |
| Notes: | "MedlineLiu, Ying-Juan Guo, Hui-Fen Zhang, Jian-Xu Zhang, Yao-Hua eng Research Support, Non-U.S. Gov't England 2017/05/20 Sci Rep. 2017 May 18; 7(1):2094. doi: 10.1038/s41598-017-02259-1" |
