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Anal Chem

Title:		Selected ion flow tube-MS analysis of headspace vapor from gastric content for the diagnosis of gastro-esophageal cancer
Author(s):		Kumar S; Huang J; Cushnir JR; Spanel P; Smith D; Hanna GB;
Address:		"Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Wing, St Mary's Hospital, London W2 1NY, United Kingdom"
Journal Title:		Anal Chem
Year:		2012
Volume:		20121017
Issue:		21
Page Number:		9550 - 9557
DOI:		10.1021/ac302409a
ISSN/ISBN:		1520-6882 (Electronic) 0003-2700 (Linking)
Abstract:		"Gastric content is a complex biofluid within the human stomach which has an important role in digestive processes. It is believed that gastric content may be a contributory factor in the development of upper gastro-intestinal diseases. In this work, selected ion flow tube mass spectrometry (SIFT-MS) has been applied to the quantification of volatile organic compounds (VOCs) in the headspace vapor of gastric content samples, which were retrieved from three groups of patients, including those with gastro-esophageal cancer, noncancer diseases of the upper gastro-intestinal tract, and a healthy cohort. Twelve VOCs have been investigated in this study; the following 7 VOCs, acetone, formaldehyde, acetaldehyde, hexanoic acid, hydrogen sulphide, hydrogen cyanide, and methyl phenol, were found to be significantly different between cancer and healthy groups by the Mann-Whitney U test. Receiver operating characteristics (ROC) analysis was applied for the combined VOCs of acetaldehyde, formaldehyde, hydrogen sulphide, and methyl phenol to discriminate cancer patients from healthy controls. The area under the curve (AUC) was 0.9. This result raises the prospect that a VOC profile rather than a single biomarker may be preferable in the molecular-orientated diagnosis of gastro-oseophageal cancer, and this warrants further investigation to assess its potential application as a new diagnostic test"
Keywords:		Case-Control Studies Cohort Studies Esophageal Neoplasms/*chemistry/*diagnosis Humans *Mass Spectrometry Reproducibility of Results Stomach/*chemistry Volatile Organic Compounds/*analysis/chemistry Volatilization;
Notes:		"MedlineKumar, Sacheen Huang, Juzheng Cushnir, Julia R Spanel, Patrik Smith, David Hanna, George B eng Research Support, Non-U.S. Gov't 2012/10/06 Anal Chem. 2012 Nov 6; 84(21):9550-7. doi: 10.1021/ac302409a. Epub 2012 Oct 17"