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J Chromatogr

Title:		"Profiling of human body fluids in healthy and diseased states using gas chromatography and mass spectrometry, with special reference to organic acids"
Author(s):		Jellum E;
Address:
Journal Title:		J Chromatogr
Year:		1977
Volume:		143
Issue:		5
Page Number:		427 - 462
DOI:		10.1016/s0378-4347(00)81792-2
ISSN/ISBN:
Abstract:		"This review summarizes recent advances in the application of gas chromatography and mass spectrometry to the study of human diseases. Emphasis is placed upon the organic acid profiles of the various body fluids. Methods for sample work-up prior to separation and mass spectrometric analysis are reviewed, and artifacts and pitfalls are discussed. Organic acid profiles, obtained with packed or capillary columns attached to mass spectrometers with or without computer systems, have led to the discovery of new normal metabolites, new metabolic disorders, and to new knowledge about a number of other diseases. Stable isotopes and gas chromatography--mass spectrometry are suitable for quantitative analysis of many compounds in the body fluids, and well suited for investigation of metabolic pathways"
Keywords:		"Adult Body Fluids/*analysis Carboxylic Acids/*analysis/urine Chemical Phenomena Chemistry Chromatography, Gas/methods Computers Diet *Disease Humans Infant, Newborn Isotopes Mass Spectrometry/methods Metabolic Diseases/metabolism Specimen Handling Volatil;"
Notes:		"MedlineJellum, E eng Review Netherlands 1977/09/01 J Chromatogr. 1977 Sep 1; 143(5):427-62. doi: 10.1016/s0378-4347(00)81792-2"