| Title: | Prenyl proteins in eukaryotic cells: a new type of membrane anchor |
| Author(s): | Glomset JA; Gelb MH; Farnsworth CC; |
| Address: | "Howard Hughes Medical Institute Laboratory, Department of Medicine, University of Washington, Seattle 98195" |
| DOI: | 10.1016/0968-0004(90)90213-u |
| ISSN/ISBN: | 0968-0004 (Print) 0968-0004 (Linking) |
| Abstract: | "Recent studies have indicated that eukaryotic cells contain proteins that are post-translationally modified by long-chain, thioether-linked prenyl groups. These proteins include yeast mating factors, ras proteins and nuclear lamins. The modification occurs on a cysteine residue near the C terminus and appears to initiate a set of additional protein modification reactions that promote attachment of the proteins to specific membranes" |
| Keywords: | "Animals Cell Membrane/*metabolism Cells/*metabolism Eukaryotic Cells/*metabolism Humans Lamins Mating Factor Nuclear Proteins/metabolism Peptides/metabolism Polyisoprenyl Phosphates/*metabolism Protein Processing, Post-Translational Proteins/*metabolism P;" |
| Notes: | "MedlineGlomset, J A Gelb, M H Farnsworth, C C eng Review England 1990/04/01 Trends Biochem Sci. 1990 Apr; 15(4):139-42. doi: 10.1016/0968-0004(90)90213-u" |
