| Title: | Screening method for the determination of volatiles in biomedical samples by means of an off-line closed-loop trapping system and high-resolution gas chromatography-ion trap detection |
| Author(s): | Ghoos Y; Claus D; Geypens B; Hiele M; Maes B; Rutgeerts P; |
| Address: | "Department of Gastrointestinal Research, University Hospital Gasthuisberg, K.U. Leuven, Belgium" |
| DOI: | 10.1016/0021-9673(94)85062-3 |
| ISSN/ISBN: | 0021-9673 (Print) 0021-9673 (Linking) |
| Abstract: | A method is described for the analysis of volatile organic compounds in biological matrices (faeces and urine). The technique is based on off-line preconcentration by means of a closed-loop trapping system followed by high-resolution gas chromatography-ion trap detection (HRGC-ITD) for separation and identification of the compounds. The technique has been validated for pattern recognition in faecal and urine samples from healthy volunteers. It is considered a very promising tool in metabolic research |
| Keywords: | "Carbohydrates/analysis Chromatography, Gas Feces/*chemistry Fermentation Humans Hydrocarbons/*analysis Indicators and Reagents Lipids/analysis Proteins/analysis Quality Control Urine/*chemistry;" |
| Notes: | "MedlineGhoos, Y Claus, D Geypens, B Hiele, M Maes, B Rutgeerts, P eng Research Support, Non-U.S. Gov't Netherlands 1994/04/15 J Chromatogr A. 1994 Apr 15; 665(2):333-45. doi: 10.1016/0021-9673(94)85062-3" |
