| Title: | A pilot study of faecal volatile organic compounds in faeces from cholera patients in Bangladesh to determine their utility in disease diagnosis |
| Author(s): | Garner CE; Smith S; Bardhan PK; Ratcliffe NM; Probert CS; |
| Address: | "Clinical Science at South Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol BS2 8HW, UK. katy.garner@bristol.ac.uk" |
| DOI: | 10.1016/j.trstmh.2009.02.004 |
| ISSN/ISBN: | 1878-3503 (Electronic) 0035-9203 (Linking) |
| Abstract: | "The aim of this pilot study was to analyse the volatile organic compounds in faecal samples collected from cholera patients in Bangladesh to determine biomarkers that could be used for disease diagnosis. Samples were collected from patients at the International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh and also from healthy controls at the same institution. The volatile organic compounds were extracted from the headspace above the sample using solid phase microextraction and analysed using gas chromatography-mass spectrometry. A biomarker was identified in the cholera samples that could be used for disease diagnosis" |
| Keywords: | Bangladesh Biomarkers/analysis Case-Control Studies Cholera/diagnosis/*metabolism Cyclohexane Monoterpenes Cyclohexenes/analysis Disulfides/analysis Feces/*chemistry/microbiology Gas Chromatography-Mass Spectrometry Humans Monoterpenes/analysis Pilot Proj; |
| Notes: | "MedlineGarner, C E Smith, S Bardhan, P K Ratcliffe, N M Probert, C S J eng England 2009/03/10 Trans R Soc Trop Med Hyg. 2009 Nov; 103(11):1171-3. doi: 10.1016/j.trstmh.2009.02.004. Epub 2009 Mar 6" |
