| Title: | Supplementation with Two New Standardized Tea Extracts Prevents the Development of Hypertension in Mice with Metabolic Syndrome |
| Author(s): | Fuente Munoz M; Fuente Fernandez M; Roman-Carmena M; Iglesias de la Cruz MDC; Amor S; Martorell P; Enrique-Lopez M; Garcia-Villalon AL; Inarejos-Garcia AM; Granado M; |
| Address: | "Physiology Department, Faculty of Medicine, Universidad Autonoma de Madrid, 28029 Madrid, Spain. R&D Department Biopolis, 46980 Paterna, Spain. R&D Department of Functional Extracts, ADM(R), 46740 Valencia, Spain. CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, 28029 Madrid, Spain" |
| ISSN/ISBN: | 2076-3921 (Print) 2076-3921 (Electronic) 2076-3921 (Linking) |
| Abstract: | "Hypertension is considered to be both a cardiovascular disease and a risk factor for other cardiovascular diseases, such as coronary ischemia or stroke. In many cases, hypertension occurs in the context of metabolic syndrome (MetS), a condition in which other circumstances such as abdominal obesity, dyslipidemia, and insulin resistance are also present. The high incidence of MetS makes necessary the search for new strategies, ideally of natural origin and with fewer side effects than conventional pharmacological treatments. Among them, the tea plant is a good candidate, as it contains several bioactive compounds such as caffeine, volatile terpenes, organic acids, and polyphenols with positive biological effects. The aim of this study was to assess whether two new standardized tea extracts, one of white tea (WTE) and the other of black and green tea (CTE), exert beneficial effects on the cardiovascular alterations associated with MetS. For this purpose, male C57/BL6J mice were fed a standard diet (Controls), a diet high in fats and sugars (HFHS), HFHS supplemented with 1.6% WTE, or HFHS supplemented with 1.6% CTE for 20 weeks. The chromatography results showed that CTE is more concentrated on gallic acid, xanthines and flavan-3-ols than WTE. In vivo, supplementation with WTE and CTE prevented the development of MetS-associated hypertension through improved endothelial function. This improvement was associated with a lower expression of proinflammatory and prooxidant markers, and-in the case of CTE supplementation-also with a higher expression of antioxidant enzymes in arterial tissue. In conclusion, supplementation with WTE and CTE prevents the development of hypertension in obese mice; as such, they could be an interesting strategy to prevent the cardiovascular disorders associated with MetS" |
| Keywords: | antioxidant black tea extract green tea hypertension metabolic syndrome obesity white tea; |
| Notes: | "PubMed-not-MEDLINEde la Fuente Munoz, Mario de la Fuente Fernandez, Maria Roman-Carmena, Marta Iglesias de la Cruz, Maria Del Carmen Amor, Sara Martorell, Patricia Enrique-Lopez, Maria Garcia-Villalon, Angel Luis Inarejos-Garcia, Antonio Manuel Granado, Miriam eng 2nd Call of " Programa de Fomento de la Transferencia del Conocimiento UAM" /Autonomous University of Madrid/ no grant number available/ADM Wild/ Switzerland 2022/08/27 Antioxidants (Basel). 2022 Aug 15; 11(8):1573. doi: 10.3390/antiox11081573" |
