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Tsitologiia

Title:		[Olfactory stress and modification of phagocytosis in peripheral blood cells of adult male mice]
Author(s):		Daev EV; Vorob'ev KV; Zimina SA;
Address:		St. Petersburg State University
Journal Title:		Tsitologiia
Year:		2001
Volume:		43
Issue:		10
Page Number:		954 - 960
DOI:
ISSN/ISBN:		0041-3771 (Print) 0041-3771 (Linking)
Abstract:		"Data on pheromonal influence on phagocytic activity of leukocytes in peripheral blood of adult randombred and CBA male mice have been obtained. The identified mouse pheromone 2,5-dimethylpyrazine was used, which induces some physiological effects associated with reproduction in both mouse males and females. Significant differences in spontaneous level of phagocytosis were between inbred CBA and randombred animals: the frequency of phagocytic cells was lower in CBA males by 1.4 times. The substance tested here induces phagocytosis in randombred (by 1.7 times) males. A low dose of 2,5-dimethylpyrazine (similar to the natural pheromone concentration) induces a higher increase in phagocytic activity by leukocytes. Possible mechanisms of pheromonal action on phagocytosis are discussed with the perspectives of finding highly effective immunomodulators among mammalian pheromones"
Keywords:		"Animals Female Leukocytes/*physiology Male Mice Mice, Inbred CBA *Phagocytosis *Pheromones Pyrazines *Smell Stress, Physiological/chemically induced/*physiopathology;"
Notes:		"MedlineDaev, E V Vorob'ev, K V Zimina, S A rus English Abstract Russia (Federation) 2002/01/05 Tsitologiia. 2001; 43(10):954-60"