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Dev Biol

Title:		Signal propagation and regulation in the mating pheromone response pathway of the yeast Saccharomyces cerevisiae
Author(s):		Bardwell L; Cook JG; Inouye CJ; Thorner J;
Address:		"Department of Molecular and Cell Biology, University of California, Berkeley 94720-3202"
Journal Title:		Dev Biol
Year:		1994
Volume:		166
Issue:		2
Page Number:		363 - 379
DOI:		10.1006/dbio.1994.1323
ISSN/ISBN:		0012-1606 (Print) 0012-1606 (Linking)
Abstract:		"Extracellular signals can affect the rate of proliferation and the state of differentiation of eukaryotic cells. Signal transduction pathways have evolved to detect these signals at the plasma membrane, transmit them through the cytoplasm and into the nucleus, and thereby generate the appropriate changes in metabolism and transcription. Much attention has been focused recently on regulatory pathways of this sort that lead to activation of a family of protein kinases known as the mitogen- or messenger-activated, or extracellular signal-regulated protein kinases (MAPKs or ERKs) because this particular class of enzyme is highly conserved among eukaryotes, as is documented here and in the accompanying reviews in this issue. The mating pheromone response pathway in a unicellular microbe, the budding yeast Saccharomyces cerevisiae, is perhaps the best understood multicomponent signaling pathway known in any eukaryotic organism, especially at the genetic level. Furthermore, structural homologs and functional analogs of the components of the yeast pheromone response pathway are recapitulated in the signaling systems present in multicellular eukaryotes. This article emphasizes recent findings and common molecular themes for understanding the organization and regulation of MAPK-dependent signaling cascades that have emerged from biochemical and genetic analysis of the mating pheromone response pathway in yeast"
Keywords:		"*Cell Cycle GTP-Binding Proteins/*physiology Gene Expression Regulation Genes, Fungal Mating Factor Peptides/*physiology Protein Kinases/*physiology Receptors, Mating Factor Receptors, Peptide/*physiology Saccharomyces cerevisiae/*physiology Signal Transd;"
Notes:		"MedlineBardwell, L Cook, J G Inouye, C J Thorner, J eng GM07232/GM/NIGMS NIH HHS/ GM15871/GM/NIGMS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review 1994/12/01 Dev Biol. 1994 Dec; 166(2):363-79. doi: 10.1006/dbio.1994.1323"