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Trends Biotechnol

Title:		Protein- and Peptide-Based Biosensors in Artificial Olfaction
Author(s):		Barbosa AJM; Oliveira AR; Roque ACA;
Address:		"UCIBIO, Departamento de Quimica, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal. UCIBIO, Departamento de Quimica, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal. Electronic address: cecilia.roque@fct.unl.pt"
Journal Title:		Trends Biotechnol
Year:		2018
Volume:		20180910
Issue:		12
Page Number:		1244 - 1258
DOI:		10.1016/j.tibtech.2018.07.004
ISSN/ISBN:		1879-3096 (Electronic) 0167-7799 (Print) 0167-7799 (Linking)
Abstract:		"Animals' olfactory systems rely on proteins, olfactory receptors (ORs) and odorant-binding proteins (OBPs), as their native sensing units to detect odours. Recent advances demonstrate that these proteins can also be employed as molecular recognition units in gas-phase biosensors. In addition, the interactions between odorant molecules and ORs or OBPs are a source of inspiration for designing peptides with tunable odorant selectivity. We review recent progress in gas biosensors employing biological units (ORs, OBPs, and peptides) in light of future developments in artificial olfaction, emphasizing examples where biological components have been employed to detect gas-phase analytes"
Keywords:		"Biosensing Techniques/*methods/trends *Electronic Nose Odorants/*analysis Receptors, Odorant/*metabolism Volatile organic compounds artificial olfaction biosensor odorant-binding protein olfactory receptor peptide;"
Notes:		"MedlineBarbosa, Armenio J M Oliveira, Ana Rita Roque, Ana C A eng 639123/ERC_/European Research Council/International Research Support, Non-U.S. Gov't Review England 2018/09/15 Trends Biotechnol. 2018 Dec; 36(12):1244-1258. doi: 10.1016/j.tibtech.2018.07.004. Epub 2018 Sep 10"