| Title: | Suckling defect in mice lacking the soluble haemopoietin receptor NR6 |
| Author(s): | Alexander WS; Rakar S; Robb L; Farley A; Willson TA; Zhang JG; Hartley L; Kikuchi Y; Kojima T; Nomura H; Hasegawa M; Maeda M; Fabri L; Jachno K; Nash A; Metcalf D; Nicola NA; Hilton DJ; |
| Address: | "The Walter and Eliza Hall Institute of Medical Research, The Cooperative Research Centre for Cellular Growth Factors, Post Office Royal Melbourne Hospital, Victoria, 3050, Australia. alexander_w@wehi.edu.au" |
| DOI: | 10.1016/s0960-9822(99)80266-8 |
| ISSN/ISBN: | 0960-9822 (Print) 0960-9822 (Linking) |
| Abstract: | "Cytokines control a variety of cellular responses including proliferation, differentiation, survival and functional activation, via binding to specific receptors expressed on the surface of target cells [1]. The cytokine receptors of the haemopoietin family are defined by the presence of a conserved 200 amino acid extracellular domain known as the haemopoietin domain [2]. We report here the isolation of NR6, a haemopoietin receptor that, like the p40 subunit of interleukin-12 (IL-12) [3] and the EBI3 gene induced by Epstein-Barr virus infection in lymphocytes [4], contains a typical haemopoietin domain but lacks transmembrane and cytoplasmic domains. Although in situ hybridisation revealed NR6 expression at multiple sites in the developing embryo, mice lacking NR6 did not display obvious abnormalities and were born in the expected numbers. Neonatal NR6(-/-) mice failed to suckle, however, and died within 24 hours of birth, suggesting that NR6 is necessary for the recognition or processing of pheromonal signals or for the mechanics of suckling itself. In addition, NR6(-/-) mice had reduced numbers of haemopoietic progenitor cells, suggesting a potential role in the regulation of primitive haemopoiesis" |
| Keywords: | "Amino Acid Sequence Animals Animals, Suckling/*physiology Carrier Proteins/genetics/*physiology Gene Expression Regulation, Developmental Hematopoiesis/*physiology Humans Mice Mice, Knockout Molecular Sequence Data *Receptors, Cell Surface Receptors, Lept;" |
| Notes: | "MedlineAlexander, W S Rakar, S Robb, L Farley, A Willson, T A Zhang, J G Hartley, L Kikuchi, Y Kojima, T Nomura, H Hasegawa, M Maeda, M Fabri, L Jachno, K Nash, A Metcalf, D Nicola, N A Hilton, D J eng CA22556/CA/NCI NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England 1999/06/09 Curr Biol. 1999 Jun 3; 9(11):605-8. doi: 10.1016/s0960-9822(99)80266-8" |
