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J Breath Res

Title:		Factors influencing breath analysis results in patients with diabetes mellitus
Author(s):		Zhou Q; Wang Q; Chen B; Han Y; Cheng L; Shen Y; Hao P; Zhang Z;
Address:		"Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, the First Hospital Affiliated with Shandong First Medical University, Department of Cardiology, Shandong University Qilu Hospital, and School of Medicine of Shandong University, Jinan, 250012, Shandong, People's Republic of China"
Journal Title:		J Breath Res
Year:		2019
Volume:		20190906
Issue:		4
Page Number:		46012 -
DOI:		10.1088/1752-7163/ab285a
ISSN/ISBN:		1752-7163 (Electronic) 1752-7155 (Linking)
Abstract:		"Breath analysis is used to detect the composition of exhaled gas. As a quick and non-invasive detection method, breath analysis provides deep insights into the progression of various kinds of diseases, especially those with metabolism disorders. Abundant information on volatile compounds in diabetic patients has been studied in numerous articles in the literature. However, exhaled gas in diabetic patients can be altered by various complications. So far, little attention has been paid to this alteration. In our paper, we found that under air pollution conditions, diabetic patients exhale more nitric oxide. Diabetic patients with heart failure exhale more acetone than those without heart failure. After (13)C-labeled glucose intake, patients infected with Helicobacter pylori exhaled more (13)C and less (18)O than those without infection. Exhalation with chronic kidney disease changes volatile organic compounds on a large scale. Diabetic patients with ketoacidosis exhale more acetone than those without ketoacidosis. Some specific volatile organic compounds also emanate from diabetic feet. By monitoring breath frequency, diabetic patients with obstructive sleep apnea syndrome exhibit a unique breath pattern and rhythm as compared with other diabetic patients, and sleep apnea is prevalent among diabetic patients. In addition to clinical findings, we analyzed the underlying mechanisms at the levels of molecules, cells and whole bodies, and provided suggestions for further studies"
Keywords:		Air Pollution/analysis Breath Tests/*methods Diabetes Mellitus/*diagnosis Exhalation Humans Nitric Oxide Volatile Organic Compounds/analysis;
Notes:		"MedlineZhou, Qing Wang, Qiannan Chen, Bo Han, Yi Cheng, Lei Shen, Yaqian Hao, Panpan Zhang, Zhongwen eng Research Support, Non-U.S. Gov't Review England 2019/09/07 J Breath Res. 2019 Sep 6; 13(4):046012. doi: 10.1088/1752-7163/ab285a"