| Title: | New graphene fiber coating for volatile organic compounds analysis |
| Author(s): | Zhang G; Guo X; Wang S; Wang X; Zhou Y; Xu H; |
| Address: | "Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Institute of Environmental Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China. Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Institute of Environmental Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China. Electronic address: huixu@mail.ccnu.edu.cn" |
| Journal Title: | J Chromatogr B Analyt Technol Biomed Life Sci |
| DOI: | 10.1016/j.jchromb.2014.08.016 |
| ISSN/ISBN: | 1873-376X (Electronic) 1570-0232 (Linking) |
| Abstract: | "In the work, a novel graphene-based solid phase microextraction-gas chromatography/mass spectrometry method was developed for the analysis of trace amount of volatile organic compounds in human exhaled breath vapor. The graphene fiber coating was prepared by a one-step hydrothermal reduction reaction. The fiber with porous and wrinkled structure exhibited excellent extraction efficiency toward eight studied volatile organic compounds (two n-alkanes, five n-aldehydes and one aromatic compound). Meanwhile, remarkable thermal and mechanical stability, long lifespan and low cost were also obtained for the fiber. Under the optimal conditions, the developed method provided low limits of detection (1.0-4.5ngL(-1)), satisfactory reproducibility (3.8-13.8%) and acceptable recoveries (93-122%). The method was applied successfully to the analysis of breath samples of lung cancer patients and healthy individuals. The unique advantage of this approach includes simple setup, non-invasive analysis, cost-efficient and sufficient sensitivity. The proposed method supply us a new possibility to monitor volatile organic compounds in human exhaled breath samples" |
| Keywords: | Biomarkers/analysis Breath Tests/*methods Case-Control Studies Gas Chromatography-Mass Spectrometry/*methods Graphite/*chemistry Humans Limit of Detection Lung Neoplasms/metabolism Reproducibility of Results Solid Phase Microextraction/*instrumentation/me; |
| Notes: | "MedlineZhang, GuoJuan Guo, XiaoXi Wang, ShuLing Wang, XueLan Zhou, YanPing Xu, Hui eng Research Support, Non-U.S. Gov't Netherlands 2014/08/30 J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 15; 969:128-31. doi: 10.1016/j.jchromb.2014.08.016. Epub 2014 Aug 17" |
