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ACS Chem Biol

Title:		"Nematode Signaling Molecules Are Extensively Metabolized by Animals, Plants, and Microorganisms"
Author(s):		Yu Y; Zhang YK; Manohar M; Artyukhin AB; Kumari A; Tenjo-Castano FJ; Nguyen H; Routray P; Choe A; Klessig DF; Schroeder FC;
Address:		"Boyce Thompson Institute, Cornell University, Ithaca, New York 14853, United States. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States. Chemistry Department, College of Environmental Science and Forestry, State University of New York, Syracuse, New York 13210, United States. Holoclara, Inc., Pasadena, California 91101, United States"
Journal Title:		ACS Chem Biol
Year:		2021
Volume:		20210521
Issue:		6
Page Number:		1050 - 1058
DOI:		10.1021/acschembio.1c00217
ISSN/ISBN:		1554-8937 (Electronic) 1554-8929 (Print) 1554-8929 (Linking)
Abstract:		"Many bacterivorous and parasitic nematodes secrete signaling molecules called ascarosides that play a central role regulating their behavior and development. Combining stable-isotope labeling and mass spectrometry-based comparative metabolomics, here we show that ascarosides are taken up from the environment and metabolized by a wide range of phyla, including plants, fungi, bacteria, and mammals, as well as nematodes. In most tested eukaryotes and some bacteria, ascarosides are metabolized into derivatives with shortened fatty acid side chains, analogous to ascaroside biosynthesis in nematodes. In plants and C. elegans, labeled ascarosides were additionally integrated into larger, modular metabolites, and use of different ascaroside stereoisomers revealed the stereospecificity of their biosynthesis. The finding that nematodes extensively metabolize ascarosides taken up from the environment suggests that pheromone editing may play a role in conspecific and interspecific interactions. Moreover, our results indicate that plants, animals, and microorganisms may interact with associated nematodes via manipulation of ascaroside signaling"
Keywords:		Animals Bacteria/*metabolism Caenorhabditis elegans/*metabolism Glycolipids/*metabolism Metabolomics Mice Plants/*metabolism Rats Signal Transduction;
Notes:		"MedlineYu, Yan Zhang, Ying K Manohar, Murli Artyukhin, Alexander B Kumari, Anshu Tenjo-Castano, Francisco J Nguyen, Hung Routray, Pratyush Choe, Andrea Klessig, Daniel F Schroeder, Frank C eng R01 GM088290/GM/NIGMS NIH HHS/ R01 GM113692/GM/NIGMS NIH HHS/ R35 GM131877/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural 2021/05/22 ACS Chem Biol. 2021 Jun 18; 16(6):1050-1058. doi: 10.1021/acschembio.1c00217. Epub 2021 May 21"