| Title: | Indoor air pollution and human ocular diseases: Associated contaminants and underlying pathological mechanisms |
| Author(s): | Yang DL; Zhang ZN; Liu H; Yang ZY; Liu MM; Zheng QX; Chen W; Xiang P; |
| Address: | "Yunnan Province Innovative Research Team of Environmental Pollution, Food Safety, and Human Health, School of Ecology and Environment, Southwest Forestry University, Kunming, 650224, China. The Affiliated Hospital of Yunnan University, Eye Hospital of Yunnan Province, Kunming, 650224, China. The Affiliated Ningbo Eye Hospital of Wenzhou Medical University, Ningbo, 315040, China. The Affiliated Ningbo Eye Hospital of Wenzhou Medical University, Ningbo, 315040, China. Electronic address: chenweimd@wmu.edu.cn. Yunnan Province Innovative Research Team of Environmental Pollution, Food Safety, and Human Health, School of Ecology and Environment, Southwest Forestry University, Kunming, 650224, China. Electronic address: xiangping@swfu.edu.cn" |
| DOI: | 10.1016/j.chemosphere.2022.137037 |
| ISSN/ISBN: | 1879-1298 (Electronic) 0045-6535 (Linking) |
| Abstract: | "People spend a long time indoors, especially young children. The risk of indoor pollution on human health is one of the current hotspots in environmental and public health. The human ocular surface is highly susceptible to indoor environment quality. Epidemiological data have linked human ophthalmological disorders with exposure to indoor pollution. In this review, we summarized the adverse impacts of indoor pollution on the human ocular surface. Several studies demonstrated that indoor contaminants including particulate matter, volatile/semi-volatile organic compounds, heavy metals, and fuel combustion and cigarette smoke exposure were associated with the incidence of human dry eye, conjunctivitis, glaucoma, cataracts, age-related macular degeneration, and keratitis. In addition, toxicological investigations revealed that indoor pollution-induced induced chronic inflammation, oxidative damage, and disruption of tight junctions are the main underlying pathological mechanisms for ocular surface diseases. Taken together, this review may expand the understanding of pollution-induced eye disorder and highlight the importance of reducing associated contaminants to decrease their detrimental effects on human eyes" |
| Keywords: | Indoor pollution Ocular surface diseases Pathological mechanisms; |
| Notes: | "PublisherYang, Dan-Lei Zhang, Zhen-Ning Liu, Hai Yang, Zi-Yue Liu, Mi-Mi Zheng, Qin-Xiang Chen, Wei Xiang, Ping eng Review England 2022/11/10 Chemosphere. 2022 Oct 28; 311(Pt 2):137037. doi: 10.1016/j.chemosphere.2022.137037" |
