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J Insect Physiol

Title:		"Interaction of dopamine, female pheromones, locomotion and sex behavior in Drosophila melanogaster"
Author(s):		Wicker-Thomas C; Hamann M;
Address:		"LEGS, CNRS, 91198 Gif sur Yvette Cedex, France. claude.wicker-thomas@legs.cnrs-gif.fr"
Journal Title:		J Insect Physiol
Year:		2008
Volume:		20080809
Issue:		10-Nov
Page Number:		1423 - 1431
DOI:		10.1016/j.jinsphys.2008.08.005
ISSN/ISBN:		0022-1910 (Print) 0022-1910 (Linking)
Abstract:		"The regulation of female hydrocarbons and courtship behavior by dopamine and their relationship with locomotion, were investigated in Drosophila melanogaster. Ddc mutants and wild-type female flies treated with tyrosine hydroxylase inhibitors (alpha-methyltyrosine or 3-iodotyrosine) had fewer diene hydrocarbons (female pheromones) and there was a total (Ddc), partial (alpha-methyltyrosine) or no (3-iodotyrosine) rescue of hydrocarbon pattern after dopamine ingestion. There was a correlation between female pheromone level and male courtship intensity for these dopamine-depleted or rescued flies. Female locomotion was decreased in flies treated with tyrosine hydroxylase inhibitors and restored by dopamine, showing that decreased mobility of the female has little importance on male courtship. However, male courtship was inhibited by an increased mobility of dopamine-supplemented females. Tanning, which is altered in dopamine-deficient flies and in tan and ebony mutants, seemed to have no significant influence on female pheromones. Females with increased quantities of dopamine (by ingestion) exhibited larger quantities of pheromones. However, Catsup mutants did not, probably as a result of defects in the epidermis. The Dat mutation, which resulted in more dopamine being produced in the brain, showed no pheromone modification. Together, these data show a complex interaction between dopamine, female hydrocarbons, locomotion and male courtship behavior"
Keywords:		"Animals Dopamine/*physiology Drosophila melanogaster/*physiology Enzyme Inhibitors/pharmacology Female Locomotion/*physiology Male Monoiodotyrosine/pharmacology Pheromones/*physiology Sexual Behavior, Animal/*physiology Tyrosine 3-Monooxygenase/antagonist;"
Notes:		"MedlineWicker-Thomas, Claude Hamann, Mickael eng Research Support, Non-U.S. Gov't England 2008/09/03 J Insect Physiol. 2008 Oct-Nov; 54(10-11):1423-31. doi: 10.1016/j.jinsphys.2008.08.005. Epub 2008 Aug 9"