« Previous AbstractEffects of population-related variation in plant primary and secondary metabolites on aboveground and belowground multitrophic interactions    Next AbstractLight-induced migration behaviour of Daphnia modified by food and predator kairomones »

Toxicol Lett

Title:		Assessment of the absorbed dose after exposure to surgical smoke in an operating room
Author(s):		Van Gestel EAF; Linssen ES; Creta M; Poels K; Godderis L; Weyler JJ; De Schryver A; Vanoirbeek JAJ;
Address:		"IDEWE vzw, Belgium. Department of Public Health and Primary Care, Centre for Environment and Health, KU Leuven, Leuven, Belgium. IDEWE vzw, Belgium; Department of Public Health and Primary Care, Centre for Environment and Health, KU Leuven, Leuven, Belgium. Department of Epidemiology and Social Medicine, UA Statistics Centre, University of Antwerp, Antwerp, Belgium. IDEWE vzw, Belgium; Department of Epidemiology and Social Medicine, UA Statistics Centre, University of Antwerp, Antwerp, Belgium. Department of Public Health and Primary Care, Centre for Environment and Health, KU Leuven, Leuven, Belgium. Electronic address: jeroen.vanoirbeek@kuleuven.be"
Journal Title:		Toxicol Lett
Year:		2020
Volume:		20200418
Issue:
Page Number:		45 - 51
DOI:		10.1016/j.toxlet.2020.04.003
ISSN/ISBN:		1879-3169 (Electronic) 0378-4274 (Linking)
Abstract:		"Surgical smoke produced by electrosurgery contains various chemical substances such as volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs). The aim of this study is to investigate airborne concentrations of VOCs and PAHs during electrosurgery in an operating room, in relation to metabolites in urine in order to assess the absorbed dose. A 5-day exposure study was set up in a general surgery operation room including surgeons, scrub assistants and circulation nurses (n = 15). Stationary and personal air sampling for VOCs and PAHs were carried out. Pre-, mid- and end-shift analysis of urinary S-phenylmercapturic acid (SPMA), o-cresol, mandelic acid and 1-hydroxypyrene was performed to assess the internal exposure to respectively benzene, toluene, styrene and PAHs. Several VOCs (styrene, ethyl benzene, benzene and toluene), ranging from 0.7 to 3.27 mug/m(3) were detected in the air samples, along with one PAH (naphthalene, ranging from 0.012 to 0.39 mug/m(3)). There was no significant correlation between air monitoring and urinary biomonitoring. O-cresol levels were increased, especially among assistants and nurses at mid- and end-shift, exceeding current biological exposure indices several times. External and internal exposure for assistants and nurses was substantially more, compared to surgeons. This study confirms the presence of VOCs and PAHs in surgical smoke and shows the presence of their metabolites in urine, but the association is unclear. Urinary biomonitoring shows especially high concentrations of o-cresol"
Keywords:		"Air Pollutants, Occupational/*analysis/urine Biomarkers/urine *Electrosurgery Humans Medical Staff, Hospital Nursing Staff, Hospital Occupational Exposure/*analysis *Operating Rooms Polycyclic Aromatic Hydrocarbons/*analysis/urine Smoke/*analysis Volatile;"
Notes:		"MedlineVan Gestel, Ellen A F Linssen, Eveline S Creta, Matteo Poels, Katrien Godderis, Lode Weyler, Joost J De Schryver, Antoon Vanoirbeek, Jeroen A J eng Netherlands 2020/04/21 Toxicol Lett. 2020 Aug 1; 328:45-51. doi: 10.1016/j.toxlet.2020.04.003. Epub 2020 Apr 18"