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Mar Drugs

Title:		Impact of Marine Chemical Ecology Research on the Discovery and Development of New Pharmaceuticals
Author(s):		Tan LT;
Address:		"Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, Singapore 637616, Singapore"
Journal Title:		Mar Drugs
Year:		2023
Volume:		20230309
Issue:		3
Page Number:		-
DOI:		10.3390/md21030174
ISSN/ISBN:		1660-3397 (Electronic) 1660-3397 (Linking)
Abstract:		"Diverse ecologically important metabolites, such as allelochemicals, infochemicals and volatile organic chemicals, are involved in marine organismal interactions. Chemically mediated interactions between intra- and interspecific organisms can have a significant impact on community organization, population structure and ecosystem functioning. Advances in analytical techniques, microscopy and genomics are providing insights on the chemistry and functional roles of the metabolites involved in such interactions. This review highlights the targeted translational value of several marine chemical ecology-driven research studies and their impact on the sustainable discovery of novel therapeutic agents. These chemical ecology-based approaches include activated defense, allelochemicals arising from organismal interactions, spatio-temporal variations of allelochemicals and phylogeny-based approaches. In addition, innovative analytical techniques used in the mapping of surface metabolites as well as in metabolite translocation within marine holobionts are summarized. Chemical information related to the maintenance of the marine symbioses and biosyntheses of specialized compounds can be harnessed for biomedical applications, particularly in microbial fermentation and compound production. Furthermore, the impact of climate change on the chemical ecology of marine organisms-especially on the production, functionality and perception of allelochemicals-and its implications on drug discovery efforts will be presented"
Keywords:		*Ecosystem *Volatile Organic Compounds Ecology Aquatic Organisms/chemistry Pheromones/chemistry Pharmaceutical Preparations allelochemicals chemical defense climate change drug discovery infochemicals marine chemical ecology marine symbioses specialized m;
Notes:		"MedlineTan, Lik Tong eng RI2/20/TLT/National Institute of Education/ Review Switzerland 2023/03/29 Mar Drugs. 2023 Mar 9; 21(3):174. doi: 10.3390/md21030174"