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Sens Actuators B Chem

Title:		Mask assistance to colorimetric sniffers for detection of Covid-19 disease using exhaled breath metabolites
Author(s):		Bordbar MM; Samadinia H; Hajian A; Sheini A; Safaei E; Aboonajmi J; Arduini F; Sharghi H; Hashemi P; Khoshsafar H; Ghanei M; Bagheri H;
Address:		"Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Institute of Sensor and Actuator Systems, TU Wien, Gusshausstrasse 27-29, 1040 Vienna, Austria. Department of Mechanical Engineering, Shohadaye Hoveizeh Campus of Technology, Shahid Chamran University of Ahvaz, Dashte Azadegan, Khuzestan, Iran. Department of Chemistry, College of Sciences, Shiraz University, Shiraz, Iran. Department of Chemical Science and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy. Research and Development Department, Farin Behbood Tashkhis LTD, Tehran, Iran"
Journal Title:		Sens Actuators B Chem
Year:		2022
Volume:		20220714
Issue:
Page Number:		132379 -
DOI:		10.1016/j.snb.2022.132379
ISSN/ISBN:		0925-4005 (Print) 0925-4005 (Electronic) 0925-4005 (Linking)
Abstract:		"According to World Health Organization reports, large numbers of people around the globe have been infected or died for Covid-19 due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Researchers are still trying to find a rapid and accurate diagnostic method for revealing infected people by low viral load with the overriding goal of effective diagnostic management. Monitoring the body metabolic changes is known as an effective and inexpensive approach for the evaluation of the infected people. Here, an optical sniffer is introduced to detect exhaled breath metabolites of patients with Covid-19 (60 samples), healthy humans (55 samples), and cured people (15 samples), providing a unique color pattern for differentiation between the studied samples. The sniffer device is installed on a thin face mask, and directly exposed to the exhaled breath stream. The interactions occurring between the volatile compounds and sensing components such as porphyrazines, modified organic dyes, porphyrins, inorganic complexes, and gold nanoparticles allowing for the change of the color, thus being tracked as the sensor responses. The assay accuracy for the differentiation between patient, healthy and cured samples is calculated to be in the range of 80%-84%. The changes in the color of the sensor have a linear correlation with the disease severity and viral load evaluated by rRT-PCR method. Interestingly, comorbidities such as kidney, lung, and diabetes diseases as well as being a smoker may be diagnosed by the proposed method. As a powerful detection device, the breath sniffer can replace the conventional rapid test kits for medical applications"
Keywords:		Breath analysis Colorimetric sniffers Coronavirus Covid-19 detection Metabolomics Non-invasive methods;
Notes:		"PubMed-not-MEDLINEBordbar, Mohammad Mahdi Samadinia, Hosein Hajian, Ali Sheini, Azarmidokht Safaei, Elham Aboonajmi, Jasem Arduini, Fabiana Sharghi, Hashem Hashemi, Pegah Khoshsafar, Hosein Ghanei, Mostafa Bagheri, Hasan eng Switzerland 2022/07/21 Sens Actuators B Chem. 2022 Oct 15; 369:132379. doi: 10.1016/j.snb.2022.132379. Epub 2022 Jul 14"