| Title: | Biological effects of inhaled crude oil vapor V. Altered biogenic amine neurotransmitters and neural protein expression |
| Author(s): | Sriram K; Lin GX; Jefferson AM; McKinney W; Jackson MC; Cumpston JL; Cumpston JB; Leonard HD; Kashon ML; Fedan JS; |
| Address: | "Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America. Electronic address: kos4@cdc.gov. Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America" |
| DOI: | 10.1016/j.taap.2022.116137 |
| ISSN/ISBN: | 1096-0333 (Electronic) 0041-008X (Print) 0041-008X (Linking) |
| Abstract: | "Workers in the oil and gas industry are at risk for exposure to a number of physical and chemical hazards at the workplace. Chemical hazard risks include inhalation of crude oil or its volatile components. While several studies have investigated the neurotoxic effects of volatile hydrocarbons, in general, there is a paucity of studies assessing the neurotoxicity of crude oil vapor (COV). Consequent to the 2010 Deepwater Horizon (DWH) oil spill, there is growing concern about the short- and long-term health effects of exposure to COV. NIOSH surveys suggested that the DWH oil spill cleanup workers experienced neurological symptoms, including depression and mood disorders, but the health effects apart from oil dispersants were difficult to discern. To investigate the potential neurological risks of COV, male Sprague-Dawley rats were exposed by whole-body inhalation to COV (300 ppm; Macondo surrogate crude oil) following an acute (6 h/d x 1 d) or sub-chronic (6 h/d x 4 d/wk. x 4 wks) exposure regimen. At 1, 28 or 90 d post-exposure, norepinephrine (NE), epinephrine (EPI), dopamine (DA) and serotonin (5-HT) were evaluated as neurotransmitter imbalances are associated with psychosocial-, motor- and cognitive- disorders. Sub-chronic COV exposure caused significant reductions in NE, EPI and DA in the dopaminergic brain regions, striatum (STR) and midbrain (MB), and a large increase in 5-HT in the STR. Further, sub-chronic exposure to COV caused upregulation of synaptic and Parkinson's disease-related proteins in the STR and MB. Whether such effects will lead to neurodegenerative outcomes remain to be investigated" |
| Keywords: | "Animals Gases Male *Neurotoxicity Syndromes/etiology Neurotransmitter Agents *Petroleum *Petroleum Pollution Rats Rats, Sprague-Dawley Serotonin *Water Pollutants, Chemical/toxicity Brain Inhalants Inhalation studies Neurological disorders Neurotoxicity N;" |
| Notes: | "MedlineSriram, Krishnan Lin, Gary X Jefferson, Amy M McKinney, Walter Jackson, Mark C Cumpston, Jared L Cumpston, James B Leonard, Howard D Kashon, Michael L Fedan, Jeffrey S eng CC999999/ImCDC/Intramural CDC HHS/ Research Support, U.S. Gov't, P.H.S. 2022/06/25 Toxicol Appl Pharmacol. 2022 Aug 15; 449:116137. doi: 10.1016/j.taap.2022.116137. Epub 2022 Jun 21" |
