« Previous AbstractCandida biofilms: is adhesion sexy?    Next AbstractMorpho-functional identification of abdominal olfactory receptors in the midge Culicoides imicola »

Trends Microbiol

Title:		Evolution of a new signal transduction pathway in Candida albicans
Author(s):		Soll DR;
Address:		"Department of Biology, The University of Iowa, Iowa City, IA 52242, USA. david-soll@uiowa.edu"
Journal Title:		Trends Microbiol
Year:		2011
Volume:		20101029
Issue:		1
Page Number:		8 - 13
DOI:		10.1016/j.tim.2010.10.001
ISSN/ISBN:		1878-4380 (Electronic) 0966-842X (Linking)
Abstract:		"The evolution of new signal transductions pathways is poorly understood. Here I present a rare glimpse into the evolution of one such pathway, namely the white-cell pheromone response pathway in Candida albicans. In this pathway, the upper portion has been derived intact from the ancestral pathway for mating, the targeted transcription factor from an ancestral filamentation or biofilm pathway, and the upregulated genes from an ancestral biofilm pathway. Each component of this pathway, therefore, has been derived from a conserved pathway. I suggest that the evolution of this new pathway provides one possible paradigm for the evolution of other signal transduction pathways in new cell types"
Keywords:		"*Biological Evolution Candida albicans/cytology/*genetics/*metabolism Genes, Mating Type, Fungal Pheromones/metabolism *Signal Transduction;"
Notes:		"MedlineSoll, David R eng Research Support, Non-U.S. Gov't England 2010/11/03 Trends Microbiol. 2011 Jan; 19(1):8-13. doi: 10.1016/j.tim.2010.10.001. Epub 2010 Oct 29"