| Title: | "Differences in Exposure to Nicotine, Tobacco-Specific Nitrosamines, and Volatile Organic Compounds among Electronic Cigarette Users, Tobacco Smokers, and Dual Users from Three Countries" |
| Author(s): | Smith DM; Shahab L; Blount BC; Gawron M; Kosminder L; Sobczak A; Xia B; Sosnoff CS; Goniewicz ML; |
| Address: | "Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA. Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK. Tobacco and Volatiles Branch, Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. Department of General and Inorganic Chemistry, Katowice Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Jagiellonska 4, 41-200 Sosnowiec, Poland" |
| ISSN/ISBN: | 2305-6304 (Electronic) 2305-6304 (Linking) |
| Abstract: | "Country-level differences in nicotine vaping products used and biomarkers of exposure among long-term e-cigarette users and dual users remain understudied. This cross-sectional study was conducted in 2014 in the United States (n = 166), United Kingdom (n = 129), and Poland (n = 161). We compared patterns of tobacco product use and nicotine and toxicant exposure among cigarette-only smokers (n = 127); e-cigarette-only users (n = 124); dual users of tobacco cigarettes and e-cigarettes (n = 95); and non-users (control group, n = 110) across three countries using mixed-effects linear regression. Compared with cigarette smokers, e-cigarette-only users had lower levels of toxicant biomarkers, but higher levels of nicotine biomarkers. Dual users had higher levels of toxicant biomarkers than e-cigarette-only users but similar levels to cigarette-only smokers. E-cigarette users in Poland, who overwhelmingly used refillable tank devices, exhibited greater levels of nicotine, and toxicant biomarkers relative to e-cigarette users in US/UK. Despite smoking fewer cigarettes, dual users from Poland exhibited similar levels of nicotine biomarkers compared with UK dual users, but higher than US dual users. Country-level differences in e-cigarette devices used and smoking behaviors (e.g., intensity) may contribute to differences in biomarker levels among users of the same products residing in different countries" |
| Keywords: | e-cigarettes global health harm reduction nicotine toxicants vaping; |
| Notes: | "PubMed-not-MEDLINESmith, Danielle M Shahab, Lion Blount, Benjamin C Gawron, Michal Kosminder, Leon Sobczak, Andrzej Xia, Baoyun Sosnoff, Connie S Goniewicz, Maciej L eng C27061/A16929/CRUK_/Cancer Research UK/United Kingdom U54 CA228110/CA/NCI NIH HHS/ R01DA037446/DA/NIDA NIH HHS/ U54CA228110/National Cancer Institute (NCI) and Food and Drug Administration Center for Tobacco Products/ R01 DA037446/DA/NIDA NIH HHS/ Switzerland 2020/10/18 Toxics. 2020 Oct 14; 8(4):88. doi: 10.3390/toxics8040088" |
