| Title: | "Induction of wound response genes in tomato leaves by bestatin, an inhibitor of aminopeptidases" |
| Author(s): | Schaller A; Bergey DR; Ryan CA; |
| Address: | "Institute of Biological Chemistry, Washington State University, Pullman 99164-6340, USA" |
| ISSN/ISBN: | 1040-4651 (Print) 1532-298X (Electronic) 1040-4651 (Linking) |
| Abstract: | "Bestatin, an inhibitor of some aminopeptidases in plants and animals, is a powerful inducer of defense genes in tomato leaves; these genes are also induced by herbivore attacks, mechanical wounding, systemin, and methyl jasmonate. Unlike wounding and systemin, bestatin does not cause an increase in intracellular jasmonic acid concentrations, and inhibitors of the octadecanoid pathway do not inhibit induction by bestatin. Furthermore, defense genes were induced by bestatin in a mutant tomato line (JL-5) with a defect in the octadecanoid pathway. Bestatin therefore appears to be exerting its effects close to the level of transcriptional control of these genes, where it may be inhibiting a regulatory protease" |
| Keywords: | "Aminopeptidases/antagonists & inhibitors Animals Base Sequence Gene Expression/*drug effects *Genes, Plant Leucine/*analogs & derivatives/pharmacology Solanum lycopersicum/drug effects/*genetics/metabolism Molecular Sequence Data Mutation Oligonucleotide;" |
| Notes: | "MedlineSchaller, A Bergey, D R Ryan, C A eng Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England 1995/11/01 Plant Cell. 1995 Nov; 7(11):1893-8. doi: 10.1105/tpc.7.11.1893" |
