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Proc Natl Acad Sci U S A

Title:		Genetic elimination of known pheromones reveals the fundamental chemical bases of mating and isolation in Drosophila
Author(s):		Savarit F; Sureau G; Cobb M; Ferveur JF;
Address:		"Neurobiologie de l'Apprentissage et de la Memoire Mecanismes de Communication, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8620, Universite Paris Sud, 91405 Orsay, France"
Journal Title:		Proc Natl Acad Sci U S A
Year:		1999
Volume:		96
Issue:		16
Page Number:		9015 - 9020
DOI:		10.1073/pnas.96.16.9015
ISSN/ISBN:		0027-8424 (Print) 1091-6490 (Electronic) 0027-8424 (Linking)
Abstract:		"Overexpression of the UAS-tra transgene in Drosophila melanogaster females led to the complete elimination of their cuticular pheromones. According to current models of Drosophila behavior, these flies should induce no courtship. In fact, they are still attractive to conspecific males. Three classes of stimuli are shown to induce courtship, with different effects on male behavior: (i) known pheromones produced by control females, (ii) stimuli produced by living control and transgenic flies, and (iii) as-yet-undetermined pheromones present on both control and transgenic flies. Only the latter class of pheromones are required for mating. They appear to represent a layer of ancestral attractive substances present in D. melanogaster and its sibling species; known cuticular pheromones modulate this attractivity positively or negatively. The absence of inhibitory pheromones leads to high levels of interspecific mating, suggesting an important role for these cuticular hydrocarbons in isolation between species"
Keywords:		"Animals Animals, Genetically Modified Crosses, Genetic DNA-Binding Proteins Drosophila/genetics/*physiology Drosophila melanogaster/genetics/*physiology Female Fungal Proteins/biosynthesis/genetics Genotype HSP70 Heat-Shock Proteins/biosynthesis/genetics/;"
Notes:		"MedlineSavarit, F Sureau, G Cobb, M Ferveur, J F eng 1999/08/04 Proc Natl Acad Sci U S A. 1999 Aug 3; 96(16):9015-20. doi: 10.1073/pnas.96.16.9015"