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Toxicol Rep

Title:		Occupational exposure to volatile organic compounds affects microRNA profiling: Towards the identification of novel biomarkers
Author(s):		Sisto R; Capone P; Cerini L; Paci E; Pigini D; Gherardi M; Gordiani A; L'Episcopo N; Tranfo G; Chiarella P;
Address:		"Italian Workers Compensation Authority (INAIL), Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, via di Fontana Candida 1, 00078, Monte Porzio Catone, Rome, Italy"
Journal Title:		Toxicol Rep
Year:		2020
Volume:		20200603
Issue:
Page Number:		700 - 710
DOI:		10.1016/j.toxrep.2020.05.006
ISSN/ISBN:		2214-7500 (Electronic) 2214-7500 (Linking)
Abstract:		"In the framework of a project aimed at finding novel predictive biomarkers of VOCs exposure-related diseases, the effect of exposure to ethylbenzene, toluene, and xylene has been analyzed in a group of painters (spray- and roller-painters) working in the shipyard industry. Airborne levels of solvents were higher in spray- than in roller-painters, and comparable to the Occupational Exposure Limits (OELs), particularly for toluene and xylene. The urinary concentration of each volatile organic compound (VOC) and of the corresponding metabolites were also concurrently measured. A set of oxidative stress biomarkers, i.e., the products of DNA and RNA oxidation, RNA methylation, and protein nitration, were measured, and found significantly higher at the end of the work shift. MicroRNA (MiRNA) expression was analyzed in the VOC-exposed workers and in a control group, finding 56 differentially expressed (DE) miRNAs at a statistically significant level (adjusted p
Keywords:		"Biological monitoring DE, differently expressed KEGG, Kyoto Encyclopedia of Genes and Genomes MHIPPA, methylhippuric acid OELs, Occupational Exposure Limits Painting SBMA, S-Benzylmercapturic acid SPMA, S- Phenylmercapturic acid Urinary biomarkers VOCs VO;"
Notes:		"PubMed-not-MEDLINESisto, Renata Capone, Pasquale Cerini, Luigi Paci, Enrico Pigini, Daniela Gherardi, Monica Gordiani, Andrea L'Episcopo, Nunziata Tranfo, Giovanna Chiarella, Pieranna eng Ireland 2020/06/20 Toxicol Rep. 2020 Jun 3; 7:700-710. doi: 10.1016/j.toxrep.2020.05.006. eCollection 2020"