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Izv Akad Nauk Ser Biol

Title:		[Detection of Volatile Organic Compounds Associated with Hepatocellular Carcinoma by Macrosmatic Animals: Approaches to the Search for New Tumor Markers]
Author(s):		Rodionova EI; Kochevalinaa MY; Kotenkova EV; Morozova V; Kogun GA; Bataeva EL; Ambaryan AV;
Address:
Journal Title:		Izv Akad Nauk Ser Biol
Year:		2015
Volume:
Issue:		3
Page Number:		293 - 301
DOI:
ISSN/ISBN:		1026-3470 (Print) 1026-3470 (Linking)
Abstract:		"Macrosmatic animals (dogs and mice) have been proved to be able to distinguish between the urine or feces of mice with transplanted hepatocellular carcinoma and those of healthy mice by odor. The chemical composition of animal excreta was found to change with tumor growth; however, it is not clear yet if this results from tumor growth itself, inflammation, or immune response. We suggested that the use of the ability of macrosmatic animals to compare odor mixtures combined with mouse cancer models is a promising trend in the search for new tumor markers"
Keywords:		"Animals Biomarkers, Tumor/*urine Carcinoma, Hepatocellular/*urine Dogs Liver Neoplasms/*urine Mice Odorants *Smell Volatile Organic Compounds/urine;"
Notes:		"MedlineRodionova, E I Kochevalinaa, M Yu Kotenkova, E V Morozova, V Kogun, G A Bataeva, E L Ambaryan, A V rus Russia (Federation) 2015/09/10 Izv Akad Nauk Ser Biol. 2015 May-Jun; (3):293-301"