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J Med Entomol

Title:		Electroantennogram and behavioral responses of Culex quinquefasciatus (Diptera: Culicidae) females to chemicals found in human skin emanations
Author(s):		Puri SN; Mendki MJ; Sukumaran D; Ganesan K; Prakash S; Sekhar K;
Address:		"Defense Research and Development Establishment, Jhansi Road, Gwalior 474002, India"
Journal Title:		J Med Entomol
Year:		2006
Volume:		43
Issue:		2
Page Number:		207 - 213
DOI:		10.1603/0022-2585(2006)043[0207:eabroc]2.0.co;2
ISSN/ISBN:		0022-2585 (Print) 0022-2585 (Linking)
Abstract:		"The southern house mosquito, Culex quinquefasciatus Say (Diptera: Culicidae), is closely associated with humans and is a vector of filariasis. Use of semiochemicals for control of mosquitoes is a novel and potentially ecofriendly control approach. Human skin emanations are known to attract mosquitoes. In the current study, olfactory and behavioral responses of host-seeking female Cx. quinquefasciatus to various chemical components of human skin emanations (carboxylic acids, alcohols, and aldehydes) were evaluated separately at three doses (0.01, 0.1, and 1 microg) for electroantennogram (EAG) and three doses (0.1, 1, and 10 microg) for behavioral assay. Results of EAG studies indicated that all carboxylic acids elicited significant olfactory responses except tetradecanoic acid (C14) and octadecanoic acid (C18). In particular, hexanoic acid (C6) elicited a maximum, eight-fold olfactory response compared with the solvent control. Ethylene glycol and benzyl alcohol exhibited significant EAG and behavioral responses, whereas among aldehydes, nonanal elicited high EAG and behavioral responses, but only at all three doses tested compared with control. Some carboxylic acids elicited significant behavioral responses, attracting approximately 75% of females tested toward chemical stimuli in a Y-tube olfactometer"
Keywords:		"Alcohols/*pharmacology Aldehydes/*pharmacology Animals Behavior, Animal/drug effects/physiology Carboxylic Acids/*pharmacology Culex/drug effects/*physiology Electrochemistry Female Flight, Animal/physiology Humans Insect Vectors/drug effects/*physiology;"
Notes:		"MedlinePuri, Sarika N Mendki, M J Sukumaran, D Ganesan, K Prakash, Shri Sekhar, K eng Research Support, Non-U.S. Gov't England 2006/04/20 J Med Entomol. 2006 Mar; 43(2):207-13. doi: 10.1603/0022-2585(2006)043[0207:eabroc]2.0.co; 2"