| Title: | Evaluation of Resistance to Fescue Toxicosis in Purebred Angus Cattle Utilizing Animal Performance and Cytokine Response |
| Author(s): | Poole DH; Mayberry KJ; Newsome M; Poole RK; Galliou JM; Khanal P; Poore MH; Serao NVL; |
| Address: | "Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA. Director of Agriculture, The Biltmore Company, Asheville, NC 28803, USA. Department of Animal Science, Texas A&M University, College Station, TX 77843, USA. Department of Animal Science, Iowa State University, Ames, IA 50011, USA" |
| ISSN/ISBN: | 2072-6651 (Electronic) 2072-6651 (Linking) |
| Abstract: | "Fescue toxicosis is a multifaceted syndrome common in cattle grazing endophyte-infected tall fescue; however, varying symptomatic responses potentially imply genetic tolerance to the syndrome. It was hypothesized that a subpopulation of animals within a herd would develop tolerance to ergot alkaloid toxicity. Therefore, the goals of this study were to develop selection criteria to identify tolerant and susceptible animals within a herd based on animal performance, and then examine responsive phenotypic and cytokine profiles to fescue toxicosis. Angus cows grazed endophyte-infected tall fescue at two locations for 13 weeks starting in mid-April 2016. Forage measurements were collected to evaluate ergot alkaloid exposure during the study. A post hoc analysis of animal performance was utilized to designate cattle into either tolerant or susceptible groups, and weekly physiological measurements and blood samples were collected to evaluate responses to chronic exposure to endophyte-infected tall fescue. Findings from this study support the proposed fescue toxicosis selection method formulated herein, could accurately distinguish between tolerant and susceptible animals based on the performance parameters in cattle chronically exposed to ergot alkaloids, and provides evidence to warrant additional analysis to examine the impact of ergot alkaloids on immune responsiveness in cattle experiencing fescue toxicosis" |
| Keywords: | "Animal Feed/analysis/toxicity Animals Behavior, Animal/drug effects/physiology Cattle Cattle Diseases/chemically induced/*metabolism/microbiology Cytokines/*metabolism Ergot Alkaloids/analysis/*toxicity Herbivory/*drug effects/*physiology Poaceae/microbio;" |
| Notes: | "MedlinePoole, Daniel H Mayberry, Kyle J Newsome, McKayla Poole, Rebecca K Galliou, Justine M Khanal, Piush Poore, Matthew H Serao, Nick V L eng DP16-03/North Carolina Cattlemens Association/International DP16-03KJM and DP16-03PK/North Carolina Agricultural Foundation, Inc./International 02420 and 02655/Hatch Project/International Research Support, Non-U.S. Gov't Switzerland 2020/12/18 Toxins (Basel). 2020 Dec 14; 12(12):796. doi: 10.3390/toxins12120796" |
