| Title: | Exhaled volatile organic compounds in patients with non-small cell lung cancer: cross sectional and nested short-term follow-up study |
| Author(s): | Poli D; Carbognani P; Corradi M; Goldoni M; Acampa O; Balbi B; Bianchi L; Rusca M; Mutti A; |
| Address: | "National Institute of Occupational Safety and Prevention Research Center, University of Parma, Via Gramsci 14, 43100 Parma, Italy. dpoli7@unipr.it" |
| ISSN/ISBN: | 1465-993X (Electronic) 1465-9921 (Print) 1465-9921 (Linking) |
| Abstract: | "BACKGROUND: Non-invasive diagnostic strategies aimed at identifying biomarkers of lung cancer are of great interest for early cancer detection. The aim of this study was to set up a new method for identifying and quantifying volatile organic compounds (VOCs) in exhaled air of patients with non-small cells lung cancer (NSCLC), by comparing the levels with those obtained from healthy smokers and non-smokers, and patients with chronic obstructive pulmonary disease. The VOC collection and analyses were repeated three weeks after the NSCLC patients underwent lung surgery. METHODS: The subjects' breath was collected in a Teflon bulb that traps the last portion of single slow vital capacity. The 13 VOCs selected for this study were concentrated using a solid phase microextraction technique and subsequently analysed by means of gas cromatography/mass spectrometry. RESULTS: The levels of the selected VOCs ranged from 10(-12) M for styrene to 10(-9) M for isoprene. None of VOCs alone discriminated the study groups, and so it was not possible to identify one single chemical compound as a specific lung cancer biomarker. However, multinomial logistic regression analysis showed that VOC profile can correctly classify about 80% of cases. Only isoprene and decane levels significantly decreased after surgery. CONCLUSION: As the combination of the 13 VOCs allowed the correct classification of the cases into groups, together with conventional diagnostic approaches, VOC analysis could be used as a complementary test for the early diagnosis of lung cancer. Its possible use in the follow-up of operated patients cannot be recommended on the basis of the results of our short-term nested study" |
| Keywords: | "Aged Biomarkers, Tumor/analysis Breath Tests/*methods Carcinoma, Non-Small-Cell Lung/*diagnosis/*metabolism Cross-Sectional Studies Exhalation Female Follow-Up Studies Humans Lung Neoplasms/*diagnosis/*metabolism/surgery Male Middle Aged Organic Chemicals;" |
| Notes: | "MedlinePoli, Diana Carbognani, Paolo Corradi, Massimo Goldoni, Matteo Acampa, Olga Balbi, Bruno Bianchi, Luca Rusca, Michele Mutti, Antonio eng R01 HL072323/HL/NHLBI NIH HHS/ R01 HL072323-03/HL/NHLBI NIH HHS/ R01 HL72323/HL/NHLBI NIH HHS/ Controlled Clinical Trial Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England 2005/07/16 Respir Res. 2005 Jul 14; 6(1):71. doi: 10.1186/1465-9921-6-71" |
