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Biomed Res Int

Title:		Comparison of Phytochemical Constituents and Pharmacological Activities of Various Solvent Extracts Obtained from Millettia speciosa Stem Powder
Author(s):		Nasiruddin; Chen G; Li X; Minghui J; Masood T; Safir W; Khan MA; Numan M; Khan A; Zeeshan M; Zeb S;
Address:		"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry & Chemical Engineering, Hainan Normal University, Haikou 571127, China. Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China. Agriculture Research Institute, Tarnab, Peshawar, Pakistan. Department of Agriculture Chemistry, The University of Agriculture, Peshawar, Pakistan. Department of Biochemistry & Molecular Biology, Xinjiang University, China. Department of Horticulture, Abdul Wali Khan University, Mardan, Pakistan"
Journal Title:		Biomed Res Int
Year:		2022
Volume:		20221116
Issue:
Page Number:		2486979 -
DOI:		10.1155/2022/2486979
ISSN/ISBN:		2314-6141 (Electronic) 2314-6133 (Print)
Abstract:		"Millettia speciosa is a plant extensively used as an important component in Chinese herbal medicine and food-based medicines. The present study was carried out to determine the total flavonoid content (TFC), volatile phytoconstituents, and pharmacological activities, i.e., antityrosinase, sunscreen, and anticancer activity, of different fractions of M. speciosa stem. Different organic solvents of increasing polarity, i.e., petroleum ether (PE), ethyl acetate (EtOAc), and methanol (MeOH), were used for extraction. The highest total flavonoid content, i.e., 48.30 +/- 0.90%, was reported for PE extract. Various important phytocomponents were revealed by gas chromatography-mass spectroscopy (GC-MS) analysis. Based on abundance, the major compounds were n-hexadecanoic acid (16.654%), n-hexadecanoic acid (14.808%), and beta-sitosterol (6.298%) for PE, EtOAc, and MeOH extract, respectively. The significant antityrosinase activity, i.e., 70.97 +/- 0.66%, with an IC(50) value of 4.58 mg/mL was noted for PE extract followed by EtOAc extract, i.e., 59.84 +/- 0.67%, with IC(50) value of 6.10 mg/mL. The maximum sunscreen activity was reported for PE extract exhibiting the maximum absorbance value (0.633 +/- 0.06) in the ultraviolet (UV) region, i.e., UVC, while EtOAc extract showed the second highest level of absorbance in the UVB range, i.e., 0.632 +/- 0.07. The strongest anticancer activity (49.73 +/- 0.49% cell viability) towards MCF-7 breast cancer cell line was reported for PE extract with IC(50) 197.51 mug/mL. Our results confirmed the presence of potential therapeutic components for each extract with significant biological functions, showing the importance of the M. speciosa stem as a source of biomedicine. To our knowledge, this is the first report on M. speciosa stem extending comprehensive research about its phytochemical profile and various significant pharmacological activities"
Keywords:		Powders Solvents *Millettia Plant Extracts/pharmacology/chemistry Sunscreening Agents Palmitic Acid Phytochemicals/pharmacology Flavonoids/pharmacology/analysis Emollients Methanol;
Notes:		"MedlineNasiruddin Chen, Guangying Li, Xiaobao Minghui, Ji Masood, Tariq Safir, Waqas Khan, Muhammad Ali Numan, Muhammad Khan, Arsalan Zeeshan, Muhammad Zeb, Shah eng 2022/11/29 Biomed Res Int. 2022 Nov 16; 2022:2486979. doi: 10.1155/2022/2486979. eCollection 2022"