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Int J Environ Res Public Health

Title:		A novel methodology to evaluate health impacts caused by VOC exposures using real-time VOC and Holter monitors
Author(s):		Mizukoshi A; Kumagai K; Yamamoto N; Noguchi M; Yoshiuchi K; Kumano H; Yanagisawa Y;
Address:		"Tokyo Metropolitan Industrial Technology Research Institute, Nishigaoka, 3-13-10, Kita-ku, Tokyo 115-8586, Japan. atsushi_mizukoshi@yy.k.u-tokyo.ac.jp"
Journal Title:		Int J Environ Res Public Health
Year:		2010
Volume:		20101130
Issue:		12
Page Number:		4127 - 4138
DOI:		10.3390/ijerph7124127
ISSN/ISBN:		1660-4601 (Electronic) 1661-7827 (Print) 1660-4601 (Linking)
Abstract:		"While various volatile organic compounds (VOCs) are known to show neurotoxic effects, the detailed mechanisms of the action of VOCs on the autonomic nervous system are not fully understood, partially because objective and quantitative measures to indicate neural abnormalities are still under development. Nevertheless, heart rate variability (HRV) has been recently proposed as an indicative measure of the autonomic effects. In this study, we used HRV as an indicative measure of the autonomic effects to relate their values to the personal concentrations of VOCs measured by a real-time VOC monitor. The measurements were conducted for 24 hours on seven healthy subjects under usual daily life conditions. The results showed HF powers were significantly decreased for six subjects when the changes of total volatile organic compound (TVOC) concentrations were large, indicating a suppression of parasympathetic nervous activity induced by the exposure to VOCs. The present study indicated these real-time monitoring was useful to characterize the trends of VOC exposures and their effects on autonomic nervous system"
Keywords:		"Adult Air Pollution, Indoor/*analysis Electrocardiography, Ambulatory/methods Environmental Monitoring/instrumentation/*methods Female Heart Rate/drug effects Humans Japan Male Middle Aged Parasympathetic Nervous System/*drug effects Volatile Organic Comp;"
Notes:		"MedlineMizukoshi, Atsushi Kumagai, Kazukiyo Yamamoto, Naomichi Noguchi, Miyuki Yoshiuchi, Kazuhiro Kumano, Hiroaki Yanagisawa, Yukio eng Research Support, Non-U.S. Gov't Switzerland 2011/02/15 Int J Environ Res Public Health. 2010 Dec; 7(12):4127-38. doi: 10.3390/ijerph7124127. Epub 2010 Nov 30"