| Title: | NCD3G: a novel nine-cysteine domain in family 3 GPCRs |
| Author(s): | Liu X; He Q; Studholme DJ; Wu Q; Liang S; Yu L; |
| Address: | "State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Handan Road 220, Shanghai 200433, P.R. China" |
| DOI: | 10.1016/j.tibs.2004.07.009 |
| ISSN/ISBN: | 0968-0004 (Print) 0968-0004 (Linking) |
| Abstract: | "The NCD3G [for nine-cysteine domain of family 3 G-protein-coupled receptors (GPCRs)] domain is a novel protein domain that is conserved in family 3 GPCRs, including metabotropic glutamate receptors, calcium-sensing receptors, pheromone receptors and taste receptors, with the exception of GABA(B) receptors. The NCD3G domain contains nine highly conserved cysteine residues. Structural predictions suggest that NCD3G might possess four beta strands and three disulfide bridges. The structural model of NCD3G highlights the conserved residues co-segregated with certain familial diseases" |
| Keywords: | "Amino Acid Sequence Animals Conserved Sequence Cystine Humans Models, Molecular Molecular Sequence Data Protein Conformation Receptors, G-Protein-Coupled/*chemistry/physiology Sequence Alignment Sequence Homology, Amino Acid;" |
| Notes: | "MedlineLiu, Xianghua He, Quanyuan Studholme, David J Wu, Qi Liang, Songping Yu, Long eng Research Support, Non-U.S. Gov't England 2004/09/01 Trends Biochem Sci. 2004 Sep; 29(9):458-61. doi: 10.1016/j.tibs.2004.07.009" |
