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Genetics


Title:Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiae
Author(s):Liu C; Lustig AJ;
Address:"Cornell University, Graduate School of Medical Sciences, New York, New York 10021, USA"
Journal Title:Genetics
Year:1996
Volume:143
Issue:1
Page Number:81 - 93
DOI: 10.1093/genetics/143.1.81
ISSN/ISBN:0016-6731 (Print) 0016-6731 (Linking)
Abstract:"We have identified three SIR3 suppressors of the telomeric silencing defects conferred by missense mutations within the Rap1p C-terminal tail domain (aa 800-827). Each SIR3 suppressor was also capable of suppressing a rap1 allele (rap1-21), which deletes the 28 aa C-terminal tail domain, but none of the suppressors restored telometric silencing to a 165 amino acid truncation allele. These data suggest a Rap1p site for Sir3p association between the two truncation points (aa 664-799). In SIR3 suppressor strains lacking the Rap1p C-terminal tail domain, the presence of a second intragenic mutation within the rap1s domain (aa 727-747), enhanced silencing 30-300-fold. These data suggest a competition between Sir3p and factors that interfere with silencing for association in the rap1s domain. Rap1-21 strains containing both wild-type Sir3p and either of the Sir3 suppressor proteins displayed a 400-4000-fold increase in telomeric silencing over rap1-21 strains carrying either Sir3p suppressor in the absence of wild-type Sir3p. We propose that this telomere-specific synergism is mediated in part through stabilization of Rap1p/Sir3p telometric complexes by Sir3p-Sir3p interactions"
Keywords:"Alleles Binding Sites Chromosomes, Fungal Fungal Proteins/*genetics/metabolism GTP-Binding Proteins/*genetics/metabolism *Genes, Fungal Genotype Mating Factor Peptide Biosynthesis Peptides/*genetics Restriction Mapping Saccharomyces cerevisiae/*genetics/m;"
Notes:"MedlineLiu, C Lustig, A J eng NCI-P30-CA08748/CA/NCI NIH HHS/ Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. 1996/05/01 Genetics. 1996 May; 143(1):81-93. doi: 10.1093/genetics/143.1.81"

 
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