| Title: | "Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes--current status and future opportunities" |
| Address: | "Institute of Biological Chemistry and MJ Murdock Metabolomics Laboratory, Washington State University, Pullman, WA, USA. lange-m@wsu.edu" |
| ISSN/ISBN: | 1467-7652 (Electronic) 1467-7644 (Linking) |
| Abstract: | "Terpenoids (a.k.a. isoprenoids) represent the most diverse class of natural products found in plants, with tens of thousands of reported structures. Plant-derived terpenoids have a multitude of pharmaceutical and industrial applications, but the natural resources for their extraction are often limited and, in many cases, synthetic routes are not commercially viable. Some of the most valuable terpenoids are not accumulated in model plants or crops, and genetic resources for breeding of terpenoid natural product traits are thus poorly developed. At present, metabolic engineering, either in the native producer or a heterologous host, is the only realistic alternative to improve yield and accessibility. In this review article, we will evaluate the state of the art of modulating the biosynthetic pathways for the production of mono-, sesqui- and diterpenes in plants" |
| Keywords: | "Artemisinins Biosynthetic Pathways Diterpenes/*metabolism Herbivory *Metabolic Engineering Monoterpenes/*metabolism Odorants Oils, Volatile/metabolism Paclitaxel Plants/*metabolism Sesquiterpenes/*metabolism Volatile Organic Compounds/metabolism;" |
| Notes: | "MedlineLange, B Markus Ahkami, Amirhossein eng Research Support, U.S. Gov't, Non-P.H.S. Review England 2012/11/23 Plant Biotechnol J. 2013 Feb; 11(2):169-96. doi: 10.1111/pbi.12022. Epub 2012 Nov 21" |
