| Title: | Low-level hydrogen sulfide and central nervous system dysfunction |
| Author(s): | Kilburn KH; Thrasher JD; Gray MR; |
| Address: | "Neuro-test Inc., University of Southern California, Keck School of Medicine, Laboratory for Environmental Sciences, Pasadena, CA 91107, USA. khkilburn@sbcglobal.net" |
| ISSN/ISBN: | 1477-0393 (Electronic) 0748-2337 (Linking) |
| Abstract: | "Forty-nine adults living in Lovington, Tatum, and Artesia, the sour gas/oil sector of Southeastern New Mexico, were tested for neurobehavioral impairment. Contributing hydrogen sulfide were (1) an anaerobic sewage plant; (2) two oil refineries; (3) natural gas/oil wells and (4) a cheese-manufacturing plant and its waste lagoons. Comparisons were to unexposed Wickenburg, Arizona, adults. Neurobehavioral functions were measured in 26 Lovington adults including 23 people from Tatum and Artesia, New Mexico, and 42 unexposed Arizona people. Participants completed questionnaires including chemical exposures, symptom frequencies and the Profile of Mood States. Measurements included balance, reaction time, color discrimination, blink reflex, visual fields, grip strength, hearing, vibration, problem solving, verbal recall, long-term memory, peg placement, trail making and fingertip number writing errors (FTNWE). Average numbers of abnormalities and test scores were adjusted for age, gender, educational level, height and weight, expressed as percent predicted (% pred) and compared by analysis of variance (ANOVA). Ages and educational attainment of the three groups were not statistically significantly different (ssd). Mean values of Lovington residents were ssd from the unexposed Arizona people for simple and choice reaction times, balance with eyes open and closed, visual field score, hearing and grip strength. Culture Fair, digit symbol substitution, vocabulary, verbal recall, peg placement, trail making A and B, FTNWE, information, picture completion and similarities were also ssd. The Lovington adults who averaged 11.8 abnormalities were ssd from, Tatum-Artesia adults who had 3.6 and from unexposed subjects with 2.0. Multiple source community hydrogen sulfide exposures impaired neurobehavioral functions" |
| Keywords: | Adult Air Pollutants/*poisoning Analysis of Variance Central Nervous System Diseases/*chemically induced Environmental Exposure Female Humans Hydrogen Sulfide/*poisoning Industrial Waste *Industry Male Middle Aged Mood Disorders/epidemiology New Mexico Oc; |
| Notes: | "MedlineKilburn, Kaye H Thrasher, Jack D Gray, Michael R eng England 2010/05/28 Toxicol Ind Health. 2010 Aug; 26(7):387-405. doi: 10.1177/0748233710369126. Epub 2010 May 26" |
