| Title: | Effects of a combination of hinokitiol (beta-thujaplicin) and an organic acid mixture on ruminal fermentation in heifers fed a high-grain diet |
| Author(s): | Ishii J; Omura H; Mitsui T; Eguchi N; Ueno T; Goto H; Ito H; |
| Address: | "Research and Development Center of Feed & Livestock Development Division, Nippon Formula Feed Manufacturing Company Limited, Motegi, Tochigi, Japan. jyunichiro.ishii@nippai.co.jp" |
| DOI: | 10.1111/j.1740-0929.2011.00915.x |
| ISSN/ISBN: | 1740-0929 (Electronic) 1344-3941 (Linking) |
| Abstract: | "This study evaluated the effects of hinokitiol (a natural antibacterial compound extracted from Thujopsis dolabrata var. hondai) and an organic acid mixture (citrate content 50%) on ruminal fermentation. Antibacterial properties were examined by measuring minimal inhibitory concentration. Hinokitiol at 1.56microg/mL or an organic acid mixture at 1600microg/mL inhibited Streptococcus bovis growth. The combination of 0.78microg/mL hinokitiol and 200microg/mL of an organic acid mixture also inhibited S. bovis growth. Both hinokitiol and the hinokitiol and an organic acid mixture combination showed strong antibacterial properties on Gram-positive bacteria such as S. bovis, but relatively weak antibacterial activities on Gram-negative bacteria such as Megasphaera elsdenii. Three ruminally cannulated heifers were fed a bloat-producing diet containing barley, pelleted alfalfa meal, soybean meal and salt without long-cut roughage to investigate the ruminal characteristics in vivo. Feeding to heifers a bloat-producing diet containing 7.8mg/kg hinokitiol and 0.2% of an organic acid mixture significantly decreased the increase in stable ingesta volume. Hinokitiol or an organic acid mixture did not affect ruminal volatile fatty acids, protozoa and bacteria. These results suggest that a combination of hinokitiol and an organic acid mixture might reduce frothy bloat in cattle fed high-grain diets" |
| Keywords: | "*Animal Feed Animals Anti-Infective Agents/*pharmacology Cattle Citric Acid/*pharmacology *Diet Digestion/drug effects Drug Resistance, Bacterial *Edible Grain Female Fermentation/*drug effects Megasphaera/drug effects Monoterpenes/*pharmacology Rumen/*mi;" |
| Notes: | "MedlineIshii, Junichiro Omura, Hiroshi Mitsui, Tadao Eguchi, Norichika Ueno, Takashi Goto, Hisaya Ito, Hiroshi eng Australia 2012/01/19 Anim Sci J. 2012 Jan; 83(1):36-42. doi: 10.1111/j.1740-0929.2011.00915.x. Epub 2011 Jul 18" |
