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J Chem Ecol

Title:		Odorant receptor from the southern house mosquito narrowly tuned to the oviposition attractant skatole
Author(s):		Hughes DT; Pelletier J; Luetje CW; Leal WS;
Address:		"Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA"
Journal Title:		J Chem Ecol
Year:		2010
Volume:		20100711
Issue:		8
Page Number:		797 - 800
DOI:		10.1007/s10886-010-9828-9
ISSN/ISBN:		1573-1561 (Electronic) 0098-0331 (Print) 0098-0331 (Linking)
Abstract:		"Oviposition attractants are environmental cues that allow Culex gravid female mosquitoes to locate suitable sites for egg-laying and, therefore, may be exploited for environmentally friendly strategies for controlling mosquito populations. Naturally occurring skatole has been identified as an oviposition attractant for the Southern House mosquito, Culex quinquefasciatus. Previously, we identified in Cx. quinquefasciatus female antennae an olfactory receptor neuron (ORN) highly sensitive to skatole and an odorant-binding protein involved in the detection of this semiochemical. Here, we describe the characterization of an odorant receptor (OR), CquiOR10, which is narrowly tuned to skatole when expressed in the Xenopus oocyte system. Odorant-induced response profiles generated by heterologously expressed CquiOR10 suggest that this OR is expressed in the mosquito ORN sensitive to skatole. However, geranylacetone, which stimulates the antennal ORN, was not detected by CquiOR10-expressing oocytes, thus raising interesting questions about reception of oviposition attractants in mosquitoes"
Keywords:		"Animals Cues Culex/*drug effects/*metabolism/physiology Dose-Response Relationship, Drug Female Gene Expression Regulation/drug effects Oviposition/*drug effects Receptors, Odorant/*metabolism Skatole/*pharmacology;"
Notes:		"MedlineHughes, David T Pelletier, Julien Luetje, Charles W Leal, Walter S eng R01 DC011091/DC/NIDCD NIH HHS/ DC011091/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. 2010/07/14 J Chem Ecol. 2010 Aug; 36(8):797-800. doi: 10.1007/s10886-010-9828-9. Epub 2010 Jul 11"