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Trends Genet

Title:		Mating-type gene switching in Saccharomyces cerevisiae
Author(s):		Haber JE;
Address:		"Rosenstiel Center, Brandeis University, Waltham, MA 02254"
Journal Title:		Trends Genet
Year:		1992
Volume:		8
Issue:		12
Page Number:		446 - 452
DOI:		10.1016/0168-9525(92)90329-3
ISSN/ISBN:		0168-9525 (Print) 0168-9525 (Linking)
Abstract:		"The study of yeast mating-type (MAT) gene switching has provided insights into several aspects of the regulation of gene expression. MAT switching is accomplished by a highly programmed site-specific homologous recombination event in which mating-type-specific sequences at MAT are replaced by alternative DNA sequences copied from one of two unexpressed donors. The mating-type system has also provided an opportunity to study both the genetic regulation of gene silencing by alterations in chromatin structure, and the basis of preferential recombination between a recipient of genetic information and one of several possible donors"
Keywords:		"Alleles Fungal Proteins/*genetics *Gene Conversion *Gene Expression Regulation, Fungal *Gene Rearrangement *Genes, Fungal Mating Factor Mitosis Models, Genetic Peptides/*genetics Pheromones/*genetics Recombination, Genetic Reproduction/genetics Saccharomy;"
Notes:		"MedlineHaber, J E eng GM20056/GM/NIGMS NIH HHS/ Research Support, U.S. Gov't, P.H.S. Review England 1992/12/01 Trends Genet. 1992 Dec; 8(12):446-52. doi: 10.1016/0168-9525(92)90329-3"