| Title: | Ecological adaptation during incipient speciation revealed by precise gene replacement |
| Author(s): | Greenberg AJ; Moran JR; Coyne JA; Wu CI; |
| Address: | "Department of Ecology and Evolution, The University of Chicago, Chicago, IL 60637, USA" |
| ISSN/ISBN: | 1095-9203 (Electronic) 0036-8075 (Linking) |
| Abstract: | "To understand the role of adaptation in speciation, one must characterize the ecologically relevant phenotypic effects of naturally occurring alleles at loci potentially causing reproductive isolation. The desaturase2 gene of Drosophila melanogaster is such a locus. Two geographically differentiated ds2 alleles underlie a pheromonal difference between the Zimbabwe and Cosmopolitan races. We used a site-directed gene replacement technique to introduce an allele of ds2 from the Zimbabwe population into Cosmopolitan flies. We show that the Cosmopolitan allele confers resistance to cold as well as susceptibility to starvation when the entire genetic background is otherwise identical. We conclude that ecological adaptation likely accompanies sexual isolation between the two behavioral races of D. melanogaster" |
| Keywords: | "*Adaptation, Physiological Africa Alkadienes/analysis Alkenes/analysis Alleles Animals *Biological Evolution Body Constitution Caribbean Region Cold Temperature Drosophila Proteins/*genetics/physiology Drosophila melanogaster/enzymology/*genetics/*physiol;" |
| Notes: | "MedlineGreenberg, Anthony J Moran, Jennifer R Coyne, Jerry A Wu, Chung-I eng Research Support, U.S. Gov't, P.H.S. 2003/12/06 Science. 2003 Dec 5; 302(5651):1754-7. doi: 10.1126/science.1090432" |
