« Previous AbstractEfficient secretion of human parathyroid hormone by Saccharomyces cerevisiae    Next AbstractChanges in Volatile Compound Profiles in Cold-Pressed Oils Obtained from Various Seeds during Accelerated Storage »

Sci Rep

Title:		Dengue virus infection changes Aedes aegypti oviposition olfactory preferences
Author(s):		Gaburro J; Paradkar PN; Klein M; Bhatti A; Nahavandi S; Duchemin JB;
Address:		"CSIRO Health and Biosecurity, Australian Animal Health Laboratory, Geelong, Australia. Institute for Intelligent Systems Research and Innovation (IISRI), Deakin University, Waurn Ponds, Australia. CSIRO Health and Biosecurity, Australian Animal Health Laboratory, Geelong, Australia. Jean-Bernard.Duchemin@csiro.au"
Journal Title:		Sci Rep
Year:		2018
Volume:		20180904
Issue:		1
Page Number:		13179 -
DOI:		10.1038/s41598-018-31608-x
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"Aedes aegypti mosquitoes, main vectors for numerous flaviviruses, have olfactory preferences and are capable of olfactory learning especially when seeking their required environmental conditions to lay their eggs. In this study, we showed that semiochemical conditions during Aedes aegypti larval rearing affected future female choice for oviposition: water-reared mosquitoes preferred to lay eggs in water or p-cresol containers, while skatole reared mosquitoes preferred skatole sites. Using two independent behavioural assays, we showed that this skatole preference was lost in mosquitoes infected with dengue virus. Viral RNA was extracted from infected female mosquito heads, and an increase of virus load was detected from 3 to 10 days post infection, indicating replication in the insect head and possibly in the central nervous system. Expression of selected genes, potentially implied in olfactory learning processes, were also altered during dengue infection. Based on these results, we hypothesise that dengue virus infection alters gene expression in the mosquito's head and is associated with a loss of olfactory preferences, possibly modifying oviposition site choice of female mosquitoes"
Keywords:		Aedes/*anatomy & histology/virology Animals Dengue/transmission Dengue Virus/isolation & purification/*physiology Female Humans Larva/anatomy & histology/virology Mosquito Vectors/*anatomy & histology/virology *Oviposition;
Notes:		"MedlineGaburro, Julie Paradkar, Prasad N Klein, Melissa Bhatti, Asim Nahavandi, Saeid Duchemin, Jean-Bernard eng England 2018/09/06 Sci Rep. 2018 Sep 4; 8(1):13179. doi: 10.1038/s41598-018-31608-x"