| Title: | Human Indoor Exposome of Chemicals in Dust and Risk Prioritization Using EPA's ToxCast Database |
| Author(s): | Dong T; Zhang Y; Jia S; Shang H; Fang W; Chen D; Fang M; |
| Address: | "School of Environment , Jinan University , Guangdong Guangzhou , P. R. China 511443. School of Civil and Environmental Engineering , Nanyang Technological University , Singapore , Singapore 639798. Residues and Resource Reclamation Centre, Nanyang Environment & Water Research Institute , Nanyang Technological University , Singapore , Singapore 637141. Singapore Phenome Center, Lee Kong Chian School of Medicine , Nanyang Technological University , Singapore , Singapore 636921" |
| ISSN/ISBN: | 1520-5851 (Electronic) 0013-936X (Linking) |
| Abstract: | "Humans spend most of their time indoors and thus have long-term exposure to chemicals. Dust is a sink for most indoor chemicals, and its ingestion is an important pathway for chemical uptake. Therefore, the chemical atlas from dust is an ideal environmental sample to investigate the indoor exposome and associated risk. In this study, we aimed to establish an indoor exposome database through comprehensive data mining on the occurrence of identified compounds in dust, and we prioritize chemicals of health concern. Through an extensive literature review (2849 articles), 355 chemicals and their concentrations were documented and analyzed for human exposure. Together with 81 compounds without concentration and 75 volatile organic compounds, we have established an indoor exposome database with 511 chemicals. Sixteen toxicological end points were selected for toxicity prioritization. Toxic equivalency factor (TEF)-based toxicity, calculated from EPA's ToxCast database, revealed a comprehensive atlas of the chemicals that had a primary contribution. Many of the prioritized compounds are currently neglected or are not actively studied. Overall, this investigation provides one of the most comprehensive analyses on chemical occurrence in indoor dust and prioritizes their chemical toxicity. Our findings can be used as a database for future exposome studies of the indoor environment and provide guidance for indoor risk assessments" |
| Keywords: | "*Air Pollution, Indoor Databases, Factual Dust Humans *Volatile Organic Compounds;" |
| Notes: | "MedlineDong, Ting Zhang, Yingdan Jia, Shenglan Shang, Hongtao Fang, Wenjuan Chen, Da Fang, Mingliang eng Research Support, Non-U.S. Gov't Review 2019/05/14 Environ Sci Technol. 2019 Jun 18; 53(12):7045-7054. doi: 10.1021/acs.est.9b00280. Epub 2019 May 28" |
